INT273933

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 37
Disease Relevance 17.95
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crem) DNA binding (Crem)
Anatomy Link Frequency
nucleus accumbens 8
neuronal 4
neurons 4
forebrain 4
hippocampus 4
Crem (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 37 99.98 Very High Very High Very High
Hippocampus 185 99.84 Very High Very High Very High
orphanin 74 99.72 Very High Very High Very High
Nucleus accumbens 185 99.68 Very High Very High Very High
depression 111 99.64 Very High Very High Very High
antagonist 111 99.52 Very High Very High Very High
antidepressant 148 99.34 Very High Very High Very High
agonist 37 99.20 Very High Very High Very High
Eae 259 98.96 Very High Very High Very High
primary somatosensory cortex 37 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 407 99.98 Very High Very High Very High
Anxiety Disorder 444 99.72 Very High Very High Very High
Death 74 99.72 Very High Very High Very High
Targeted Disruption 888 99.64 Very High Very High Very High
Depression 111 99.64 Very High Very High Very High
Apoptosis 296 98.32 Very High Very High Very High
Injury 37 96.84 Very High Very High Very High
Drug Induced Neurotoxicity 37 96.52 Very High Very High Very High
Convulsion 370 96.00 Very High Very High Very High
Herpes Simplex Virus 37 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither overexpression nor deletion of ICER affected memory tested in the odor discrimination task [21].
Neg (Neither) Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER
1) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.28 Pain Relevance 0.03
Different types of stress, as well as CRH injections, increase ICER expression in a variety of neuroendocrine structures as well as in the striatum [12, 44–46].
Positive_regulation (increase) of Gene_expression (expression) of ICER in striatum associated with stress
2) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.51 Pain Relevance 0.43
Although rAAV-mediated ICER overexpression was widespread and robust, it did not cover 100% of hippocampal neurons.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER in neurons
3) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.19 Pain Relevance 0.12
Stimuli evoking neuronal cell death in the brain upregulate endogenous ICER expression [39].
Positive_regulation (upregulate) of Gene_expression (expression) of ICER in neuronal associated with death
4) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.66 Pain Relevance 0
The overexpression of ICER in dorsal hippocampus through a recombinant adeno-associated virus (rAAV) vector did not cause 3-month-old rats to show changes in memory tests, which included a passive avoidance task and the Barnes spatial maze [20].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER in hippocampus associated with hippocampus
5) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.10 Pain Relevance 0.14
Overexpression of ICER led to impaired long-term tone- and context-dependent fear memory, leaving short-term memory unchanged (Fig. 2a).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ICER associated with anxiety disorder
6) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 1.04 Pain Relevance 0.04
The results showing that overexpression of ICER specifically impairs long-term fear memory resemble those reported previously in mice in the case of CREB downregulation [75, 82, 89] or overexpression of dominant negative mutant CREB [90, 91] and are consistent with the role of ICER as an endogenous CREB antagonist.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER associated with antagonist and anxiety disorder
7) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.53 Pain Relevance 0.04
Antidepressant and amphetamine treatments also upregulate ICER expression [46, 47], as do lithium chloride and nociceptin injections [48–50].
Positive_regulation (upregulate) of Gene_expression (expression) of ICER associated with antidepressant and orphanin
8) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.50 Pain Relevance 0.42
However, while considering these results, one needs to be aware that the consequences of stable and long-lasting overexpression of ICER may be different from the consequences of the phasic, transient changes in gene expression that takes place under normal conditions in response to different incoming stimuli [46].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER
9) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.21 Pain Relevance 0
It might also be the case that ICER-induced inhibition of transcription play a crucial role in “single-trial” or “sub-threshold” learning, but more robust repeated training (as in an odor discrimination task) is able to overcome the effects of loss or overexpression of ICER.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER
10) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.25 Pain Relevance 0.07
On the other hand, overexpression of ICER in the nucleus accumbens decreases the spontaneous activity of rats in the open field but strongly potentiates amphetamine-induced locomotor activity [46].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER in nucleus accumbens associated with nucleus accumbens and eae
11) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.64 Pain Relevance 0.27
Overexpression of ICER, achieved through gene manipulation or viral vectors, is a powerful tool.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ICER
12) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.24 Pain Relevance 0
Interestingly, some cell culture studies showed that histone deacetylase (HDAC) is required for the induction of ICER expression [36, 37].
Positive_regulation (induction) of Gene_expression (expression) of ICER
13) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.37 Pain Relevance 0.34
Moreover, overexpression of ICER in hippocampus does not lead to changes in rat locomotor activity [20].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER in hippocampus associated with eae and hippocampus
14) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.71 Pain Relevance 0.26
In addition, overexpression of ICER in the nucleus accumbens strongly potentiates amphetamine-induced locomotor activity [46].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER in nucleus accumbens associated with nucleus accumbens and eae
15) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.15 Pain Relevance 0.35
Endogenous ICER expression is also upregulated in a variety of cell cultures undergoing apoptosis [59–62].
Positive_regulation (upregulated) of Gene_expression (expression) of ICER associated with apoptosis
16) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.78 Pain Relevance 0
Moreover, both adenoviral vector-driven overexpression of ICER II?
Positive_regulation (overexpression) of Gene_expression (overexpression) of ICER II
17) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.87 Pain Relevance 0
Exploration of enriched environments upregulates ICER expression in the barrel-related columns of primary somatosensory cortex, an important site related to familiarization with novel environments and learning about new stimuli [31, 32].
Positive_regulation (upregulates) of Gene_expression (expression) of ICER in primary somatosensory cortex associated with primary somatosensory cortex
18) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.08 Pain Relevance 0.13
Purely physiological stimulation, such as exposure of dark-reared rats to light [39] and exploration of enriched environments [31, 32], also have the capacity to substantially upregulate ICER expression.
Positive_regulation (upregulate) of Gene_expression (expression) of ICER
19) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.46 Pain Relevance 0.34
Stress induces ICER expression in different parts of the HPA axis, and ICER regulates transcription of the CRH gene during stress [24, 25, 45].
Positive_regulation (induces) of Gene_expression (expression) of ICER associated with stress
20) Confidence 0.69 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.94 Pain Relevance 0.25

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