INT273935

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crem, Egr2) DNA binding (Crem, Egr2) intracellular (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
neuronal 2
Crem (Mus musculus)
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 1 96.88 Very High Very High Very High
Somatostatin 1 96.04 Very High Very High Very High
gABA 1 87.52 High High
Nucleus accumbens 5 81.64 Quite High
orphanin 2 69.80 Quite High
Eae 7 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 1 79.72 Quite High
Herpes Simplex Virus 1 79.52 Quite High
Convulsion 10 36.44 Quite Low
Repression 2 28.24 Quite Low
Stress 11 13.44 Low Low
Targeted Disruption 24 5.00 Very Low Very Low Very Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Being an inducible and powerful repressor of cAMP-dependent transcription, ICER can potentially affect the expression of numerous CRE-containing genes, including genes whose products are critically involved in neuronal plasticity; genes that encode transcription factors (c-fos, JunD, Krox-20, Krox-24, creb, icer); genes that encode neurotransmission-related proteins (enkephalin, galanin, somatostatin, CRH, tyrosine hydroxylase, GABAA receptor subunits, ?
ICER Regulation (affect) of Gene_expression (expression) of Krox-20 in neuronal associated with somatostatin and enkephalin
1) Confidence 0.05 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.16 Pain Relevance 0.26

General Comments

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