INT273943

Context Info Confidence 0.44 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0

nucleus (Creb1, Crem) DNA binding (Creb1, Crem) mitochondrion (Creb1) transcription factor binding (Creb1)

Creb1 (Mus musculus) Crem (Mus musculus)

Pain Link Frequency Relevance Heat addiction 4 32.48 Neurotransmitter 1 22.52 Dopamine 5 21.84 Catecholamine 1 10.76 Eae 7 5.00 Nucleus accumbens 5 5.00 Hippocampus 5 5.00 antidepressant 4 5.00 antagonist 3 5.00 depression 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 24 66.16 Stress 11 39.52 Anxiety Disorder 12 38.00 Drug Dependence 4 32.48 Brain Injury 1 31.68 Disease 1 31.12 Convulsion 10 5.00 Apoptosis 8 5.00 Epilepsy 6 5.00 Depression 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Phosphorylated CREB also activates P2 promoter and initiates ICER transcription.

CREB Positive_regulation (initiates) of Transcription (transcription) of ICER

1) Confidence 0.44 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.07 Pain Relevance 0

General Comments

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