INT273955

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Context Info
Confidence 0.14
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) DNA binding (Creb1) response to stress (Crh)
cytoplasm (Crh) extracellular space (Crh) extracellular region (Crh)
Creb1 (Mus musculus)
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
depression 3 89.76 High High
Eae 7 82.36 Quite High
antidepressant 4 80.88 Quite High
Nucleus accumbens 5 76.04 Quite High
tricyclic antidepressant 1 62.80 Quite High
Desipramine 2 56.00 Quite High
Hippocampus 5 18.00 Low Low
Dopamine 5 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 11 99.38 Very High Very High Very High
Depression 3 89.76 High High
Targeted Disruption 24 83.88 Quite High
Anxiety Disorder 12 73.88 Quite High
Convulsion 10 16.16 Low Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Epilepsy 6 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low
Status Epilepticus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under normal conditions, stimulation of the cAMP cascade by stress produces a dual effect: first facilitating CRH gene transcription via phospho-CREB, and later inhibiting it via induction of ICER.
phospho-CREB Positive_regulation (facilitating) of Transcription (transcription) of CRH gene associated with stress
1) Confidence 0.14 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.96 Pain Relevance 0.33

General Comments

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