INT273993

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sarcomere 2
cardiac myocytes 2
heart 2
lever 1
Hcr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1 24.64 Low Low
antagonist 1 23.36 Low Low
narcan 1 22.48 Low Low
isoflurane 80 5.00 Very Low Very Low Very Low
imagery 48 5.00 Very Low Very Low Very Low
anesthesia 16 5.00 Very Low Very Low Very Low
beta blocker 16 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 16 99.60 Very High Very High Very High
Hypoxia 512 99.32 Very High Very High Very High
Body Weight 63 94.56 High High
Myocardial Infarction 144 93.76 High High
Stress 80 84.16 Quite High
Heart Rate Under Development 64 80.56 Quite High
Heart Disease 16 73.60 Quite High
Thyroid Disease 16 59.20 Quite High
Metabolic Syndrome 208 5.00 Very Low Very Low Very Low
Cardiovascular Disease 64 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hemodynamic function of LCR and HCR rats was measured during extended exposure to a controlled state of hypoxia.
Gene_expression (rats) of HCR associated with hypoxia
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.71 Pain Relevance 0
Functional analysis of LCR and HCR isolated cardiac myocytes
Gene_expression (analysis) of HCR in cardiac myocytes
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.49 Pain Relevance 0
Left ventricular geometrical measures, however, showed a significantly larger ventricular diastolic dimension in LCR rats compared to HCR rats (LVDd [LCR] 9.1±0.2 vs.
Gene_expression (rats) of HCR
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.26 Pain Relevance 0
Overall, these data showed minor differences in heart performance under resting conditions between LCR and HCR rats.
Gene_expression (rats) of HCR in heart
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.12 Pain Relevance 0
There were no differences in the relative abundance of transcripts for these markers in LCR hearts compared to HCR hearts (Table S1).
Gene_expression (hearts) of HCR in hearts
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.15 Pain Relevance 0
Analysis of cardiac protein expression in LCR and HCR rats
Gene_expression (rats) of HCR
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0 Pain Relevance 0
Compared to myocytes derived from HCR hearts, LCR myocytes had significantly shorter resting sarcomere lengths and slower kinetics of contraction (time to peak: [LCR] 166.0±4.9 vs.
Gene_expression (hearts) of HCR in sarcomere
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.19 Pain Relevance 0
The hypothesis was tested that differences in heritable oxygen carrying capacity [23] would result in diverging cardiac responses between LCR and HCR animals during an acute hypoxic challenge in vivo.
Gene_expression (animals) of HCR associated with hypoxia
8) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.61 Pain Relevance 0
However, during dobutamine infusion, LCR rats continued to maintain a significantly higher stroke volume compared to HCR rats ([LCR] 110.2±11.6 vs.
Gene_expression (rats) of HCR associated with stroke
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.18 Pain Relevance 0
By comparison, the current study used rats selected for 19 generations which showed further divergence in native aerobic running capacity between LCR and HCR rats.
Gene_expression (rats) of HCR
10) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.06 Pain Relevance 0
To assess this, LCR and HCR rats were exposed to hypoxia (ventilation with 7% oxygen) and assessed for cardiac function and survival with real-time in vivo conductance micromanometry analysis (Figure 4, Table 3).
Gene_expression (rats) of HCR associated with hypoxia
11) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.64 Pain Relevance 0
To test this, cardiac myocytes were isolated from adult LCR and HCR rats and assessed for contractile properties.
Gene_expression (rats) of HCR in cardiac myocytes
12) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.39 Pain Relevance 0
-adrenergic signaling, no differences in cardiovascular performance were observed between LCR and HCR rats (Figure 3 and Table 3).
Gene_expression (rats) of HCR
13) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.21 Pain Relevance 0
The underlying etiology of cardiac pump failure was further analyzed to determine the mechanism of decompensation observed in HCR and LCR animals during this acute hypoxic challenge.
Gene_expression (animals) of HCR associated with hypoxia
14) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.74 Pain Relevance 0
Based on functional differences in sarcomere shortening and calcium transient kinetics, we sought to determine whether subcellular alterations in protein expression between LCR and HCR rats could explain these findings.
Gene_expression (rats) of HCR in sarcomere
15) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0 Pain Relevance 0
Based on analysis of systolic, diastolic and mean pressure measurements, these data showed that HCR and LCR rats had no statistically significant difference in mean arterial pressure ([LCR] 113.7±4.7 vs.
Gene_expression (rats) of HCR
16) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699480 Disease Relevance 0.34 Pain Relevance 0
The performance in PR for SCM revealed significant higher total lever presses and HCR for mid-pubertal pd 50 rats compared to pd 40 pubertal and adult animals.
Gene_expression (presses) of HCR in lever
17) Confidence 0.31 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2914567 Disease Relevance 0.08 Pain Relevance 0

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