INT274062

Context Info Confidence 0.06 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.00 Pain Relevance 0

plasma membrane (EGF, EGFR, TXK) extracellular space (EGF, EGFR) nucleus (EGFR, TXK) cytoplasm (EGFR, TXK) signal transduction (EGF, EGFR) extracellular region (EGF, EGFR)

EGF (Homo sapiens) EGFR (Homo sapiens) TXK (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 5 5.00 pruritus 1 5.00 Pain score 1 5.00 positron emission tomography 1 5.00

Disease Link Frequency Relevance Heat Carcinoma 1 99.76 Cancer 7 96.56 Adhesions 1 76.40 Apoptosis 2 73.12 Solid Tumor 2 70.04 Colon Cancer 17 67.32 Pancreatic Cancer 6 66.16 Non-small-cell Lung Cancer 12 65.36 Metastasis 2 64.24 Immunotherapy Of Cancer 1 54.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activation of EGFR by ligands, such as EGF, leads to receptor dimerization and activation of intrinsic tyrosine kinase (TK) activity.

EGF Positive_regulation (Activation) of EGFR Positive_regulation (leads) of Positive_regulation (activation) of tyrosine kinase

1) Confidence 0.06 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2699661 Disease Relevance 1.00 Pain Relevance 0

General Comments

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