INT274068

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.85
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Map3k5) cytoplasm (Map3k5)
Anatomy Link Frequency
retinas 2
neurons 2
Map3k5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 57 52.48 Quite High
Central nervous system 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 69 98.80 Very High Very High Very High
Death 54 98.80 Very High Very High Very High
Stroke 3 85.36 High High
Apoptosis 30 63.08 Quite High
Necrosis 9 61.68 Quite High
Cancer 6 61.32 Quite High
Cv Unclassified Under Development 54 52.48 Quite High
Injury 9 10.44 Low Low
Reperfusion Injury 18 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggested that the increased expression of ASK1 was associated with neuronal death mainly in the GCL of ischemic retinas.
Positive_regulation (increased) of Gene_expression (expression) of ASK1 in retinas associated with death
1) Confidence 0.53 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.13 Pain Relevance 0
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Positive_regulation (increased) of Gene_expression (expression) of ASK1
2) Confidence 0.38 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.98 Pain Relevance 0
Although the increased expression of ASK1 and SEK1/MEK4 in degenerating neurons may have a causal relationship, further study is needed to examine the causal relationship between ER stress and ASK1-SEK1/MEK4 expression in degenerating neurons of ischemic retinas.
Positive_regulation (increased) of Gene_expression (expression) of ASK1 in neurons associated with stress
3) Confidence 0.36 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.75 Pain Relevance 0.03

General Comments

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