INT274071

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Map3k5) cytoplasm (Map3k5)
Anatomy Link Frequency
retinas 1
Map3k5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 19 98.92 Very High Very High Very High
ischemia 38 76.96 Quite High
Central nervous system 38 59.56 Quite High
cINOD 2 34.56 Quite Low
Calcium channel 1 32.48 Quite Low
antagonist 3 31.80 Quite Low
chemokine 25 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 26 98.92 Very High Very High Very High
Death 48 98.48 Very High Very High Very High
Ganglion Cysts 8 95.36 Very High Very High Very High
Stress 60 93.36 High High
Infection 34 93.32 High High
Viral Meningitis 2 77.20 Quite High
Cv Unclassified Under Development 36 76.96 Quite High
Reperfusion Injury 12 75.76 Quite High
Stroke 3 72.76 Quite High
Brain Hemorrhage 1 72.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ischemic retinas, the numbers of SEK1-, ASK1-, and JNK-positive cells were significantly increased in the GCL compared to those in the control retinas.
Positive_regulation (increased) of ASK1 in retinas
1) Confidence 0.38 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2699777 Disease Relevance 0.69 Pain Relevance 0.11
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Positive_regulation (increased) of ASK1
2) Confidence 0.38 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.98 Pain Relevance 0
Moreover, minocycline can inhibit ASK1 activation and disrupts the cyclical inflammation/virus replication that is often the precursor to the encephalitic state (Zink et al. 2005).
Positive_regulation (activation) of ASK1 associated with inflammation
3) Confidence 0.07 Published 2010 Journal J Neuroimmune Pharmacol Section Body Doc Link PMC2914283 Disease Relevance 0.64 Pain Relevance 0.11

General Comments

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