INT274072

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 6.69
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Map3k5) cytoplasm (Map3k5)
Anatomy Link Frequency
retinas 5
neurons 2
Map3k5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 209 99.56 Very High Very High Very High
Central nervous system 11 5.00 Very Low Very Low Very Low
ketamine 11 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 253 99.90 Very High Very High Very High
Cv Unclassified Under Development 198 99.56 Very High Very High Very High
Death 198 99.20 Very High Very High Very High
Glaucoma 22 96.64 Very High Very High Very High
Diabetic Retinopathy 22 96.12 Very High Very High Very High
Stroke 11 84.96 Quite High
Ganglion Cysts 44 76.88 Quite High
Congenital Anomalies 22 69.12 Quite High
Apoptosis 110 68.60 Quite High
Reperfusion Injury 66 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggested that the increased expression of ASK1 was associated with neuronal death mainly in the GCL of ischemic retinas.
Gene_expression (expression) of ASK1 in retinas associated with death
1) Confidence 0.60 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.12 Pain Relevance 0
Both ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Gene_expression (expression) of ASK1
2) Confidence 0.60 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.97 Pain Relevance 0
Expression of ASK1 in ischemic retinas
Gene_expression (Expression) of ASK1 in retinas
3) Confidence 0.60 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.28 Pain Relevance 0.14
In the control retinas, few cells expressed ASK1, but in the ischemia-reperfusion retinas, ASK1 was expressed in the cells in the GCL (Figure 5A–C).
Gene_expression (expressed) of ASK1 in retinas associated with ischemia
4) Confidence 0.60 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.22 Pain Relevance 0.11
Semi-quantitative analysis of expression of ASK1, p-SEK1/MEK4, and p-JNK in the GCL
Gene_expression (expression) of ASK1
5) Confidence 0.60 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.15 Pain Relevance 0
In the control retinas, few cells expressed ASK1, but in the ischemia-reperfusion retinas, ASK1 was expressed in the cells in the GCL (Figure 5A–C).
Gene_expression (expressed) of ASK1 in retinas associated with ischemia
6) Confidence 0.60 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.23 Pain Relevance 0.11
In addition, the numbers of ASK1-, p-SEK1/MEK4-, and p-JNK-positive cells that were double stained with Fluoro-Jade B were counted in the GCL.
Gene_expression (counted) of ASK1
7) Confidence 0.52 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.13 Pain Relevance 0
, ASK1, SEK1/MEK4, and JNK expression with neuronal cell death of ischemic retinas.
Gene_expression (expression) of ASK1 in retinas associated with death
8) Confidence 0.46 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.49 Pain Relevance 0.03
Although the increased expression of ASK1 and SEK1/MEK4 in degenerating neurons may have a causal relationship, further study is needed to examine the causal relationship between ER stress and ASK1-SEK1/MEK4 expression in degenerating neurons of ischemic retinas.
Gene_expression (expression) of ASK1-SEK1 in neurons associated with stress
9) Confidence 0.46 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.68 Pain Relevance 0.03
JNK expression as well as ASK1 and SEK1/MEK4 expression in the GCL was significantly increased only at the initial phase after reperfusion.
Gene_expression (expression) of ASK1
10) Confidence 0.46 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.65 Pain Relevance 0.04
Although the increased expression of ASK1 and SEK1/MEK4 in degenerating neurons may have a causal relationship, further study is needed to examine the causal relationship between ER stress and ASK1-SEK1/MEK4 expression in degenerating neurons of ischemic retinas.
Gene_expression (expression) of ASK1 in neurons associated with stress
11) Confidence 0.46 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 0.74 Pain Relevance 0.03

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