INT27408

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Context Info
Confidence 0.80
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.18
Pain Relevance 5.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
putamen 1
digestive tract 1
body 1
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
Endogenous opioid 4 100.00 Very High Very High Very High
Catecholamine 2 99.60 Very High Very High Very High
noradrenaline 1 99.56 Very High Very High Very High
Dynorphin 9 99.22 Very High Very High Very High
headache 72 98.12 Very High Very High Very High
halothane 10 97.00 Very High Very High Very High
Opioid 10 96.08 Very High Very High Very High
midbrain 1 94.96 High High
Disease Link Frequency Relevance Heat
Schizophrenia 3 99.40 Very High Very High Very High
Skin Cancer 2 98.16 Very High Very High Very High
Post-dural Puncture Headache 51 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 96.36 Very High Very High Very High
Headache 20 92.64 High High
Pain 17 91.44 High High
Heart Rate Under Development 1 86.88 High High
Disease 1 82.64 Quite High
Diabetes Mellitus 1 82.00 Quite High
Occupational Lung Diseases 1 72.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proenkephalin A processing in the upper digestive tract: isolation and characterisation of phosphorylated N-terminally extended Met-enkephalin Arg6Phe7 variants.
Phosphorylation (phosphorylated) of Met-enkephalin in digestive tract associated with enkephalin
1) Confidence 0.80 Published 1988 Journal J. Neurochem. Section Title Doc Link 3418349 Disease Relevance 0 Pain Relevance 0.29
Melanoma cells homozygous for either the Arg151Cys variant or consensus sequence both elicited CREB phosphorylation in response to alpha-MSH in the presence of IBMX.
Phosphorylation (phosphorylation) of alpha-MSH associated with skin cancer
2) Confidence 0.72 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.17 Pain Relevance 0.32
Furthermore, a significant increase in the formation of the putative neuroleptic-like peptide fragment des-enkephalin-gamma-endorphin in postmortem schizophrenic putamen versus controls was shown.
Phosphorylation (formation) of des-enkephalin-gamma-endorphin in putamen associated with enkephalin and schizophrenia
3) Confidence 0.71 Published 1984 Journal Peptides Section Abstract Doc Link 6085162 Disease Relevance 0.35 Pain Relevance 0.14
The concentrations of met-enkephalin, dynorphin and catecholamines did not change and those of beta-endorphin, adrenocorticotrophin, arginine vasopressin and cortisol increased during halothane anaesthesia.
Phosphorylation (those) of beta-endorphin associated with dynorphin, catecholamine, halothane and enkephalin
4) Confidence 0.69 Published 1995 Journal Res. Vet. Sci. Section Abstract Doc Link 7709057 Disease Relevance 0.09 Pain Relevance 0.86
Apart from activating the body¬ís system of temperature regulation, there is also a hormonal response, which increases body metabolism and the concentrations of adrenaline, noradrenaline, adrenocorticotropic hormone (ACTH), cortisone, pro-opiomelanocortin (POMC), and ?
Phosphorylation (hormone) of ACTH in body associated with noradrenaline
5) Confidence 0.52 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734249 Disease Relevance 0.13 Pain Relevance 0.29
The several proposed mechanisms of action, involving serotoninergic, catecholaminergic, Ca2+ fluxes, protein phosphorylation, beta-endorphin production, cyclooxygenase inhibition and histamine interference are also reviewed.
Phosphorylation (phosphorylation) of beta-endorphin
6) Confidence 0.34 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942319 Disease Relevance 0.17 Pain Relevance 0.64
A novel modified form of Met-enkephalin was detected.
Phosphorylation (form) of Met-enkephalin associated with enkephalin
7) Confidence 0.18 Published 1989 Journal Peptides Section Abstract Doc Link 2608557 Disease Relevance 0 Pain Relevance 1.46
Previous studies show that Met-enkephalin, an endogenous opioid, down-regulates chemotaxis of selected chemokine receptors via phosphorylation.
Phosphorylation (phosphorylation) of Met-enkephalin associated with chemokine, endogenous opioid and enkephalin
8) Confidence 0.10 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12551901 Disease Relevance 0 Pain Relevance 0.65
Cosyntropin, a synthetic form of adrenocorticotropic hormone, has been used in the treatment of refractory PDPH.
Phosphorylation (form) of adrenocorticotropic hormone associated with headache
9) Confidence 0.02 Published 2010 Journal Anesthesiology Research and Practice Section Body Doc Link PMC2931374 Disease Relevance 1.27 Pain Relevance 1.23

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