INT274098

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.41
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
blood 1
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 36 92.92 High High
Fibrositis 2 72.44 Quite High
rheumatoid arthritis 4 71.88 Quite High
Multiple sclerosis 4 71.00 Quite High
Catecholamine 4 59.24 Quite High
cva 14 33.44 Quite Low
Calcium channel 18 5.00 Very Low Very Low Very Low
Migraine 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 202 99.84 Very High Very High Very High
Cv Unclassified Under Development 48 92.92 High High
Increased Venous Pressure Under Development 190 90.24 High High
Ocular Hypertension 46 78.16 Quite High
Disease 54 75.68 Quite High
Susac Syndrome 2 73.24 Quite High
Sleep Disorders 2 72.44 Quite High
Rheumatoid Arthritis 4 71.88 Quite High
Demyelinating Disease 4 71.00 Quite High
Syndrome 10 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary endothelial dysfunction is likely related to glaucoma, but the exact role of mediators such as NO, NOS, ET-1, and ETA/ETB in OAG pathophysiology has yet to be fully appreciated.
Regulation (role) of ETB associated with glaucoma
1) Confidence 0.33 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.67 Pain Relevance 0.18
Several recent studies have shifted the focus from solely examining ET-1 expression to investigating the role of ETA and ETB receptors in ocular blood flow.
Spec (investigating) Regulation (role) of ETB in blood
2) Confidence 0.33 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.73 Pain Relevance 0

General Comments

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