INT274104

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.66
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PLXNA2) intracellular (PLXNA2)
Anatomy Link Frequency
fibroblast 1
OCT 1
PLXNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 28 99.04 Very High Very High Very High
ischemia 1 76.84 Quite High
COX2 1 57.24 Quite High
Pain 2 52.08 Quite High
cINOD 5 44.44 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular & Orbital Inflammation 6 99.36 Very High Very High Very High
Diabetes Mellitus 7 99.12 Very High Very High Very High
Age-related Macular Degeneration 5 97.32 Very High Very High Very High
Autoimmune Disease 44 96.96 Very High Very High Very High
Pressure And Volume Under Development 10 92.24 High High
Muscle Disease 24 91.72 High High
Keratitis 2 88.72 High High
INFLAMMATION 23 88.20 High High
Retina Disease 2 82.44 Quite High
Graves' Ophthalmopathy 62 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subset of diabetics has relatively good vision and mild cystic changes on OCT.
Regulation (changes) of OCT associated with diabetes mellitus
1) Confidence 0.33 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699803 Disease Relevance 0.92 Pain Relevance 0.07
In our studies of TAO, we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens.
Spec (investigated) Regulation (targeting) of OCT in OCT
2) Confidence 0.08 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.86 Pain Relevance 0.04
A popular theory is that the primary reaction may involve antibodies targeting the TSH-r in the OCT which leads to orbital inflammation, manifest as orbital fibroblast stimulation, collagen and glycosaminoglycans (GAGS) production and associated congestive eye features.12 According to this theory, ocular myopathy is due to secondary, ischemic, damage to the eye muscles following primary OCT inflammation.
Regulation (targeting) of OCT in fibroblast associated with inflammation, muscle disease and ocular & orbital inflammation
3) Confidence 0.08 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.88 Pain Relevance 0.15

General Comments

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