INT27412

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Context Info
Confidence 0.58
First Reported 1985
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.81
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Anatomy Link Frequency
striatum 1
nucleus 1
cortex 1
CTL 1
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 23 100.00 Very High Very High Very High
5HT 6 100.00 Very High Very High Very High
Thalamus 2 99.92 Very High Very High Very High
Opioid 6 97.16 Very High Very High Very High
Nicotine 8 94.16 High High
medulla 4 92.96 High High
Nucleus accumbens 1 79.76 Quite High
antagonist 3 78.76 Quite High
dopamine receptor 1 78.32 Quite High
Ventral tegmentum 1 78.24 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 4 99.28 Very High Very High Very High
Anxiety Disorder 6 75.00 Quite High
Nociception 4 68.36 Quite High
Viral Infection 1 67.96 Quite High
Urological Neuroanatomy 2 58.92 Quite High
Pain 4 51.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study assessed alterations in mesolimbic enkephalin (ENK) mRNA levels after predator [2,5-dihydro-2,4,5-trimethylethiazoline (TMT)] and non-predator (butyric acid) odor encounter and/or light-dark (LD) testing in CD-1 mice immediately, 24, 48 and 168 h after the initial odor encounter and/or LD testing.
Regulation (alterations) of ENK associated with enkephalin
1) Confidence 0.58 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15525282 Disease Relevance 0.07 Pain Relevance 0.54
The results of this study demonstrate the immunomodulatory effects of Met-Enk on NK and CTL in influenza infected mice and suggest a potential for therapeutic applications.
Regulation (effects) of Enk in CTL associated with influenza virus infection
2) Confidence 0.44 Published 1995 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 7650294 Disease Relevance 0.38 Pain Relevance 0.14
Taken together, our results suggest that nicotinic receptors modulate Met-Enk content and PPE mRNA in the mouse striatum.
Regulation (modulate) of Enk in striatum
3) Confidence 0.44 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891117 Disease Relevance 0 Pain Relevance 0.61
In fetuses at mid-gestation (70-80 days), adrenal medullary Enk immunoreactivity was approximately 75% of maternal values.
Regulation (immunoreactivity) of Enk
4) Confidence 0.20 Published 1985 Journal Peptides Section Abstract Doc Link 4070017 Disease Relevance 0 Pain Relevance 0.42
The majority of maternal adrenal Enk immunoreactivity was found in medullary tissue, although cortex also contained low but detectable amounts.
Regulation (immunoreactivity) of Enk in cortex
5) Confidence 0.20 Published 1985 Journal Peptides Section Abstract Doc Link 4070017 Disease Relevance 0 Pain Relevance 0.27
Neither ENK nor 5HT immunoreactivity was observed in Vo.
Neg (Neither) Regulation (immunoreactivity) of ENK associated with 5ht
6) Confidence 0.08 Published 1989 Journal Synapse Section Abstract Doc Link 2609250 Disease Relevance 0.11 Pain Relevance 0.24
ENK and 5HT immunoreactivity was found in the ventrolateral quadrant and lateral margin of Vi, together with the adjacent interstitial nucleus (IN).
Regulation (immunoreactivity) of ENK in nucleus associated with 5ht
7) Confidence 0.08 Published 1989 Journal Synapse Section Abstract Doc Link 2609250 Disease Relevance 0.25 Pain Relevance 0.37

General Comments

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