INT27415

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Context Info
Confidence 0.51
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 10.99
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Got1) biosynthetic process (Got1) cellular amino acid metabolic process (Got1)
lysosome (Got1) cytoplasm (Got1)
Anatomy Link Frequency
macrophage 4
leucocyte 4
platelets 4
blood 2
liver 2
Got1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 42 100.00 Very High Very High Very High
Inflammation 10 100.00 Very High Very High Very High
Glutamate 5 100.00 Very High Very High Very High
Arthritis 3 99.36 Very High Very High Very High
Analgesic 12 98.24 Very High Very High Very High
depression 2 92.24 High High
carrageenan induced 1 89.00 High High
nud 3 87.48 High High
Pain 3 86.72 High High
aspirin 1 84.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Granuloma 3 99.60 Very High Very High Very High
Experimental Arthritis 2 99.36 Very High Very High Very High
Oliguria 1 99.04 Very High Very High Very High
Arthritis 4 98.72 Very High Very High Very High
Cv Unclassified Under Development 1 98.52 Very High Very High Very High
Pleural Effusion 1 97.76 Very High Very High Very High
Hemolysis 2 96.80 Very High Very High Very High
Shock 1 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered.
Negative_regulation (reduction) of Positive_regulation (elevation) of transaminase associated with glutamate
1) Confidence 0.51 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 7992815 Disease Relevance 0.17 Pain Relevance 0.20
Pretreatment of rats with aminoguanidine was found to prevent acetaminophen-induced hepatic necrosis and increases in serum transaminase levels.
Negative_regulation (prevent) of Positive_regulation (increases) of serum transaminase associated with necrosis and paracetamol
2) Confidence 0.44 Published 1998 Journal Hepatology Section Abstract Doc Link 9500703 Disease Relevance 0.46 Pain Relevance 0.77
It inhibited inflammation induced increase in serum transaminase levels and leucocyte counts but lacked any analgesic or anti-pyretic effects.
Negative_regulation (inhibited) of Positive_regulation (increase) of serum transaminase in leucocyte associated with inflammation and analgesic
3) Confidence 0.42 Published 1986 Journal Agents Actions Section Abstract Doc Link 3751752 Disease Relevance 0.82 Pain Relevance 0.36
After treatment with W. chinensis (300 mg/kg, p.o.) at 2, 6 and 10 hours, a reduction in the elevation of serum glutamate oxaloacetic transaminase (SGOT) and glutamate pyruvic transaminase (SGPT) levels was observed at 24 hrs after hepatotoxins were administered.
Negative_regulation (reduction) of Positive_regulation (elevation) of transaminase associated with glutamate
4) Confidence 0.37 Published 1994 Journal Am. J. Chin. Med. Section Abstract Doc Link 7992815 Disease Relevance 0.17 Pain Relevance 0.20
Pretreatment of the rats with either dextran sulfate or gadolinium chloride, two inhibitors of hepatic macrophage functioning, completely blocked hepatic necrosis, as well as increases in serum transaminase levels induced by acetaminophen.
Negative_regulation (blocked) of Positive_regulation (increases) of serum transaminase in macrophage associated with necrosis and paracetamol
5) Confidence 0.34 Published 1995 Journal Hepatology Section Abstract Doc Link 7705777 Disease Relevance 0.89 Pain Relevance 0.84
In fed rats, trimethyl, triethyl and tri-n-propyl esters prevented effectively the increase of serum transaminase activities.
Negative_regulation (prevented) of Positive_regulation (increase) of serum transaminase
6) Confidence 0.30 Published 1986 Journal Toxicol. Lett. Section Abstract Doc Link 3787669 Disease Relevance 0.17 Pain Relevance 0.17
KEY FINDINGS: Levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and alkaline phosphatases, which were increased in the serum, were found to be significantly reduced by the treatment of lutein in a dose-dependent manner, indicating that lutein may reduce the hepatotoxicity induced by these agents(. )Serum bilirubin was also significantly lower in lutein-treated groups compared with control.
Negative_regulation (reduced) of Positive_regulation (increased) of transaminase
7) Confidence 0.26 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20663040 Disease Relevance 0 Pain Relevance 0
Pretreatment of the rats with either dextran sulfate or gadolinium chloride, two inhibitors of hepatic macrophage functioning, completely blocked hepatic necrosis, as well as increases in serum transaminase levels induced by acetaminophen.
Negative_regulation (blocked) of Positive_regulation (induced) of serum transaminase in macrophage associated with necrosis and paracetamol
8) Confidence 0.25 Published 1995 Journal Hepatology Section Abstract Doc Link 7705777 Disease Relevance 0.89 Pain Relevance 0.89
In our study, supplementation with the alcoholic extract decreased the enhanced transaminase activity significantly.
Negative_regulation (decreased) of Positive_regulation (enhanced) of transaminase
9) Confidence 0.13 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.47 Pain Relevance 0
Centrilobular hepatic necrosis and elevation in transaminase activity following a toxic dose of acetaminophen were prevented by treatment with cysteamine.
Negative_regulation (prevented) of Positive_regulation (elevation) of transaminase associated with necrosis and paracetamol
10) Confidence 0.12 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2609341 Disease Relevance 0.45 Pain Relevance 0.57
The compounds prevented the inflammation induced increase in serum transaminase levels and leucocyte counts.
Negative_regulation (prevented) of Positive_regulation (increase) of serum transaminase in leucocyte associated with inflammation
11) Confidence 0.06 Published 1987 Journal Arzneimittelforschung Section Abstract Doc Link 3496890 Disease Relevance 0.97 Pain Relevance 0.31
The increase of the aspartate transaminase (AST) and the alanine transaminase (ALT) often precedes a decrease in platelets.
Negative_regulation (precedes) of Positive_regulation (increase) of transaminase in platelets
12) Confidence 0.05 Published 2000 Journal J Perinat Med Section Abstract Doc Link 11031696 Disease Relevance 1.63 Pain Relevance 0.13
The increase of the aspartate transaminase (AST) and the alanine transaminase (ALT) often precedes a decrease in platelets.
Negative_regulation (precedes) of Positive_regulation (increase) of transaminase in platelets
13) Confidence 0.05 Published 2000 Journal J Perinat Med Section Abstract Doc Link 11031696 Disease Relevance 1.63 Pain Relevance 0.13
Further, the product inhibited the increased level of serum lysosomal enzyme activity viz. serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase and the lipid peroxidation in liver.
Negative_regulation (inhibited) of Positive_regulation (increased) of glutamic oxaloacetic transaminase in liver
14) Confidence 0.05 Published 2007 Journal Indian J. Exp. Biol. Section Abstract Doc Link 17373374 Disease Relevance 0.90 Pain Relevance 0.50
Laboratory parameters disclosed elevated transaminase, lactate dehydrogenase, uric acid and D-dimer blood levels.
Negative_regulation (disclosed) of Positive_regulation (elevated) of transaminase in blood
15) Confidence 0.01 Published 2001 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 11688358 Disease Relevance 1.37 Pain Relevance 0.09

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