INT274166

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 132 81.60 Quite High
Inflammatory mediators 4 56.72 Quite High
Hippocampus 2 43.48 Quite Low
cytokine 20 39.72 Quite Low
fibrosis 6 36.72 Quite Low
antidepressant 2 25.68 Quite Low
rheumatoid arthritis 2 21.92 Low Low
Multiple sclerosis 2 19.92 Low Low
depression 4 14.92 Low Low
corticosteroid 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 26 83.92 Quite High
INFLAMMATION 144 81.60 Quite High
Asthma 94 71.84 Quite High
Pulmonary Disease 216 71.60 Quite High
Adhesions 2 64.52 Quite High
Inflammatory Bowel Disease 2 41.84 Quite Low
Cystic Fibrosis 2 37.28 Quite Low
Pulmonary Hypertension 2 34.56 Quite Low
Disease 10 24.32 Low Low
Rheumatoid Arthritis 2 21.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE 4 isoforms are regulated by extracellular signal-related protein kinase (ERK), which can phosphorylate PDE 4 (Houslay and Adams 2003).
Phosphorylation (phosphorylate) of PDE 4
1) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.30 Pain Relevance 0.08
Specifically, the side effects are believed to be associated with the so-called ‘high-affinity rolipram binding site’ (HARBS) (Barnette et al 1995; Muller et al 1996; Jacobitz et al 1996; Kelly et al 1996; Torphy 1998) and/or inhibition of the form of PDE 4 found in the CNS (Barnette et al 1996).
Phosphorylation (form) of PDE 4
2) Confidence 0.23 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.79 Pain Relevance 0.04

General Comments

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