INT274169

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk1, Pde4a) signal transduction (Mapk1, Pde4a) nucleus (Mapk1, Pde4a)
nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
Mapk1 (Mus musculus)
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 60.44 Quite High
Inflammation 132 55.44 Quite High
cytokine 20 43.44 Quite Low
Hippocampus 2 40.32 Quite Low
antidepressant 2 29.40 Quite Low
depression 4 18.64 Low Low
corticosteroid 16 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 216 75.32 Quite High
Adhesions 2 68.24 Quite High
INFLAMMATION 144 60.04 Quite High
Asthma 94 21.48 Low Low
Depression 4 18.64 Low Low
Vomiting 26 6.96 Low Low
Nicotine Addiction 24 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE 4 isoforms are regulated by extracellular signal-related protein kinase (ERK), which can phosphorylate PDE 4 (Houslay and Adams 2003).
extracellular signal-related protein kinase Regulation (regulated) of PDE 4
1) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.31 Pain Relevance 0.08
PDE 4 isoforms are regulated by extracellular signal-related protein kinase (ERK), which can phosphorylate PDE 4 (Houslay and Adams 2003).
ERK Regulation (regulated) of PDE 4
2) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.31 Pain Relevance 0.08

General Comments

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