INT274170

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.75
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il13, Il4) extracellular region (Il13, Il4) cytoplasm (Il13)
Anatomy Link Frequency
B cell 1
epithelium 1
Il13 (Mus musculus)
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 39 99.46 Very High Very High Very High
fibrosis 12 90.20 High High
Inflammation 93 89.24 High High
Inflammatory response 8 83.24 Quite High
corticosteroid 8 18.24 Low Low
chemokine 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 69 99.96 Very High Very High Very High
Anaphylactic Hypersensitivity 1 99.84 Very High Very High Very High
Pulmonary Disease 108 99.62 Very High Very High Very High
Hypersensitivity 4 99.44 Very High Very High Very High
Occupational Lung Diseases 3 92.24 High High
Fibrosis 13 90.20 High High
INFLAMMATION 100 89.24 High High
Rhinitis 16 88.44 High High
Sprains And Strains 4 70.96 Quite High
Targeted Disruption 4 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, IL-4 and IL-13 are important regulators of Siglec-F ligand expression by airway epithelium.



IL-13 Regulation (regulators) of IL-4 in epithelium
1) Confidence 0.09 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2988013 Disease Relevance 0.35 Pain Relevance 0.09
In addition, because IL-4 and IL-13 are important regulators of immediate hypersensitivity reactions by inducing B cell immunoglobulin (Ig) heavy chain class switching to the IgE isotype, the strong depletion of IL-4 levels in absence of CERK might have broader implications.
IL-13 Regulation (regulators) of IL-4 in B cell associated with hypersensitivity and anaphylactic hypersensitivity
2) Confidence 0.06 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.57 Pain Relevance 0.23
are the key cytokines in COPD, while in asthma, IL-4, IL-5, and IL-13 are more important.
IL-13 Regulation (important) of IL-4 associated with asthma, pulmonary disease and cytokine
3) Confidence 0.00 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.83 Pain Relevance 0.19

General Comments

This test has worked.

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