INT274171

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.20
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
bands 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 8 99.74 Very High Very High Very High
chemokine 57 96.50 Very High Very High Very High
Inflammation 92 94.48 High High
metalloproteinase 6 87.12 High High
cytokine 25 82.84 Quite High
Inflammatory mediators 2 78.20 Quite High
Inflammatory response 14 68.28 Quite High
Nicotine 1 63.28 Quite High
fibrosis 3 46.72 Quite Low
palliative 1 26.88 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 108 94.80 High High
INFLAMMATION 105 94.48 High High
Airway Remodeling 2 85.56 High High
Pathologic Processes 1 63.20 Quite High
Nicotine Addiction 12 59.40 Quite High
Fibrosis 3 46.72 Quite Low
Asthma 47 5.00 Very Low Very Low Very Low
Infection 30 5.00 Very Low Very Low Very Low
Sprains And Strains 26 5.00 Very Low Very Low Very Low
Death 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The only studies on GAG-bound chemokine in which CXCL8 activity was measured with and without adding soluble GAG in cell-based assays were inconclusive and contradictory with one study showing soluble GAG enhances CXCL8 binding and the other showing reduced binding [40], [41].
Negative_regulation (reduced) of CXCL8 Binding (binding) of associated with chemokine
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.15
Quantification was performed by comparing the intensity of the PCR product bands to the Quantitative Hyperladder I (Bioline) as a reference and then determining the ratio between IL-8 and ?
Spec (determining) Negative_regulation (determining) of IL-8 Binding (ratio) of in bands
2) Confidence 0.12 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0 Pain Relevance 0
Corticosteroids also do not inhibit the increased concentrations of IL-8 and TNF-?
Negative_regulation (inhibit) of IL-8 Binding (concentrations) of associated with corticosteroid
3) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.20 Pain Relevance 0.64

General Comments

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