INT274171

Context Info Confidence 0.38 First Reported 2007 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.20 Pain Relevance 0.79

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8) intracellular (IL8)

Anatomy Link Frequency bands 2 IL8 (Homo sapiens)

Pain Link Frequency Relevance Heat corticosteroid 8 99.74 chemokine 57 96.50 Inflammation 92 94.48 metalloproteinase 6 87.12 cytokine 25 82.84 Inflammatory mediators 2 78.20 Inflammatory response 14 68.28 Nicotine 1 63.28 fibrosis 3 46.72 palliative 1 26.88

Disease Link Frequency Relevance Heat Pulmonary Disease 108 94.80 INFLAMMATION 105 94.48 Airway Remodeling 2 85.56 Pathologic Processes 1 63.20 Nicotine Addiction 12 59.40 Fibrosis 3 46.72 Asthma 47 5.00 Infection 30 5.00 Sprains And Strains 26 5.00 Death 21 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The only studies on GAG-bound chemokine in which CXCL8 activity was measured with and without adding soluble GAG in cell-based assays were inconclusive and contradictory with one study showing soluble GAG enhances CXCL8 binding and the other showing reduced binding [40], [41].

Negative_regulation (reduced) of CXCL8 Binding (binding) of associated with chemokine

1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.15

Quantification was performed by comparing the intensity of the PCR product bands to the Quantitative Hyperladder I (Bioline) as a reference and then determining the ratio between IL-8 and ?

Spec (determining) Negative_regulation (determining) of IL-8 Binding (ratio) of in bands

2) Confidence 0.12 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0 Pain Relevance 0

Corticosteroids also do not inhibit the increased concentrations of IL-8 and TNF-?

Negative_regulation (inhibit) of IL-8 Binding (concentrations) of associated with corticosteroid

3) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.20 Pain Relevance 0.64

General Comments

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