INT274193

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.25
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PES1) nucleoplasm (PES1) nucleolus (PES1)
nucleus (PES1) intracellular (PES1)
Anatomy Link Frequency
blood 2
fat 1
intercostal 1
SVR 1
intestines 1
PES1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 45 98.28 Very High Very High Very High
Chronic pancreatitis 275 95.78 Very High Very High Very High
depression 10 88.80 High High
antagonist 12 70.08 Quite High
Bile 45 56.12 Quite High
Inflammation 16 32.48 Quite Low
alcohol 25 27.00 Quite Low
cytokine 3 8.64 Low Low
imagery 2 7.56 Low Low
Pain 106 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Steatorrhea 85 99.88 Very High Very High Very High
Hypoglycemia 5 99.12 Very High Very High Very High
Cystic Fibrosis 45 98.28 Very High Very High Very High
Diabetes Mellitus 37 96.96 Very High Very High Very High
Pancreatitis 275 95.78 Very High Very High Very High
Depression 9 88.80 High High
Toxicity 3 86.48 High High
Respiratory Distress 1 80.24 Quite High
Epstein-barr Virus 15 79.16 Quite High
Impaired Glucose Tolerance 5 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, with the increasing central drive to breath, the increased intercostal muscular activity outweighs the diaphragmatic activity resulting in a decreased Pga/Pes ratio and in turn, a reduced diaphragmatic motion.
Negative_regulation (decreased) of Pes in intercostal
1) Confidence 0.57 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699974 Disease Relevance 0.34 Pain Relevance 0
One randomized controlled trial with PES in patients with apancreatic diabetes revealed major difficulties with controlling blood sugars on changing from active enzyme replacement to placebo and vice versa, suggesting that enzyme adjustment should be carefully supervised in a hospital.16 In another randomized controlled trial of insulin- dependent diabetics with PEI, there were no significant differences in hemoglobin A1C, fasting glucose levels, or 2-hour postprandial glucose levels in patients receiving PES as compared to those not receiving PES.51 A reduction in mild and moderate hypoglycemia was observed in patients receiving PES and the authors concluded that PES therapy can be used safely in patients with diabetes mellitus and exocrine dysfunction.


Negative_regulation (reduction) of PES in blood associated with hypoglycemia and diabetes mellitus
2) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.85 Pain Relevance 0.12
One randomized controlled trial with PES in patients with apancreatic diabetes revealed major difficulties with controlling blood sugars on changing from active enzyme replacement to placebo and vice versa, suggesting that enzyme adjustment should be carefully supervised in a hospital.16 In another randomized controlled trial of insulin- dependent diabetics with PEI, there were no significant differences in hemoglobin A1C, fasting glucose levels, or 2-hour postprandial glucose levels in patients receiving PES as compared to those not receiving PES.51 A reduction in mild and moderate hypoglycemia was observed in patients receiving PES and the authors concluded that PES therapy can be used safely in patients with diabetes mellitus and exocrine dysfunction.


Negative_regulation (reduction) of PES in blood associated with hypoglycemia and diabetes mellitus
3) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.86 Pain Relevance 0.12
At the low intraduodenal pH levels seen in CP, dissolution of the coating of these enzymes in the duodenum is, at best, partial with a more complete dissolution occurring distally in the small bowel as the pH rises.15 Patients who receive concomitant acid suppression with enteric coated PES have improved duodenal delivery of PES and more efficient utilization of the absorptive capacity of the intestines.77
Negative_regulation (suppression) of PES in intestines associated with chronic pancreatitis
4) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.10 Pain Relevance 0.19
This was demonstrated in a prospective crossover study where the use of acid suppression with PES was associated with a marked decrease in the fat-protein content ratio in stool,81 suggesting an increase in fat absorption with a decrease in protein absorption.
Negative_regulation (suppression) of PES in fat
5) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0 Pain Relevance 0.04
Two randomized clinical trials have been conducted comparing these preparations to standard enteric coated microsphere preparations in CF patients with PEI,89,90 only one of which demonstrated reduction in steatorrhea with buffered PES.89
Negative_regulation (buffered) of PES associated with fibrosis and steatorrhea
6) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 0.28 Pain Relevance 0.13
Furthermore, the decrease of Pes may be the result of lowering of SVR and after load.
Negative_regulation (decrease) of Pes in SVR
7) Confidence 0.17 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937285 Disease Relevance 0.37 Pain Relevance 0.08
The decrease of Pes in all groups was accompanied with the reduction of MAP.
Negative_regulation (decrease) of Pes
8) Confidence 0.15 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937285 Disease Relevance 0.38 Pain Relevance 0.09
These results were similar when using high viscogenic PEs, alginate and Dx500, compared with Dx70 in an extreme hemodilution model.[9]
Negative_regulation (using) of PEs
9) Confidence 0.11 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937285 Disease Relevance 0.09 Pain Relevance 0

General Comments

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