INT274205

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.96
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
immune cell 4
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 26 100.00 Very High Very High Very High
Inflammation 160 98.16 Very High Very High Very High
Inflammatory stimuli 13 97.84 Very High Very High Very High
cytokine 36 89.12 High High
chemokine 26 87.44 High High
antagonist 6 87.04 High High
Inflammatory response 9 86.56 High High
Inflammatory marker 12 84.32 Quite High
ischemia 9 50.00 Quite Low
Arthritis 9 17.44 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 188 98.16 Very High Very High Very High
Necrosis 7 91.96 High High
Cancer 7 91.60 High High
Body Weight 16 84.20 Quite High
Adhesions 21 74.60 Quite High
Obesity 33 63.68 Quite High
Cv Unclassified Under Development 9 50.00 Quite Low
Stress 6 49.08 Quite Low
Arthritis 13 46.00 Quite Low
Injury 13 40.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, it appears that resistance training may modulate melanocortin 3 receptor expression, providing a possible mechanism for the anti-inflammatory effects of exercise training.


1.

Spec (may) Regulation (modulate) of Gene_expression (expression) of melanocortin 3 receptor associated with inflammation
1) Confidence 0.43 Published 2011 Journal Journal of Aging Research Section Abstract Doc Link PMC3022199 Disease Relevance 0.65 Pain Relevance 0.16
Inhibitory properties of a selective MC3R agonist
Regulation (selective) of Gene_expression (agonist) of MC3R associated with agonist
2) Confidence 0.39 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.44 Pain Relevance 0.27
It is possible that alterations in MC3R expression lead to sensitization of circulating immune cells to inflammatory stimuli.
Regulation (alterations) of Gene_expression (expression) of MC3R in immune cells associated with inflammatory stimuli
3) Confidence 0.26 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.58 Pain Relevance 0.38
Thus, measuring exercise-induced changes in MC3R cell-surface expression in specific immune cell populations, including monocytes, may be an important direction for future work.
Regulation (changes) of Gene_expression (expression) of MC3R in immune cell
4) Confidence 0.23 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.28 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox