INT274208

Context Info Confidence 0.14 First Reported 2008 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.15 Pain Relevance 0.13

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency neutrophils 4 granulocytes 2 lungs 2 Gsr (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 41 69.68 Inflammation 103 68.32 ischemia 6 50.00 cytokine 68 5.00 agonist 14 5.00 Inflammatory response 10 5.00 Pain 3 5.00 alcohol 3 5.00 adenocard 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Injury 9 99.56 Mycobacterial Infection 290 97.40 Infection 267 96.72 Adhesions 15 92.72 Granuloma 11 90.80 Sprains And Strains 69 89.32 Immunization 11 77.04 INFLAMMATION 110 68.32 Cryptococcus Infection 18 50.00 Cv Unclassified Under Development 6 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Within the GR-1hi population, CD11b expression was not modified by the IR injury in either WT or MC3R-null animals; however, granulocytes from IR MC3R-null animals displayed an increased CD11b expression when compared with WT animals.

Neg (not) Positive_regulation (modified) of Gene_expression (expression) of GR-1hi in granulocytes associated with injury

1) Confidence 0.14 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.27 Pain Relevance 0

Together, these data suggest that the early recruitment of Gr1+ neutrophils may play a role in regulating the adaptive T cell immunity during M.tuberculosis infection.

Positive_regulation (recruitment) of Gene_expression (neutrophils) of Gr1 in neutrophils associated with mycobacterial infection and infection

2) Confidence 0.13 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.02 Pain Relevance 0.03

To our knowledge, this is the first study to experimentally show that the accumulation of Gr1+ neutrophils in the lungs takes place prior to accumulation of adaptive T cells.

Positive_regulation (accumulation) of Gene_expression (neutrophils) of Gr1 in lungs

3) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.37 Pain Relevance 0

Our specific gating strategy for Gr-1+ cells concentrated on cells that expressed high levels of Gr-1 and were also CD11b+ and CD11c-, which are suggestive of neutrophils [46]–[49] (data not shown).

Positive_regulation (levels) of Gene_expression (expressed) of Gr-1 in neutrophils

4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731172 Disease Relevance 0.49 Pain Relevance 0.09

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