INT274228

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.82
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
thymus 2
hippocampus 2
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 52 100.00 Very High Very High Very High
Hippocampus 35 100.00 Very High Very High Very High
Central nervous system 7 79.68 Quite High
cytokine 23 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 44 100.00 Very High Very High Very High
Repression 10 99.98 Very High Very High Very High
Adhesions 70 99.20 Very High Very High Very High
Status Epilepticus 19 97.72 Very High Very High Very High
Age-related Macular Degeneration 5 88.08 High High
Carcinoma 50 87.56 High High
Breast Cancer 8 87.12 High High
Bordatella Infection 6 79.64 Quite High
Death 41 75.60 Quite High
Colon Cancer 50 74.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Bim repression resulted in the concomitant increase in Mcl-1 and Bcl-2 levels in CXCL12-producing, but not wild-type, cells mirroring our results seen in HT29 cells (Figure 4D).
Positive_regulation (resulted) of Positive_regulation (increase) of CXCL12-producing associated with repression
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.46 Pain Relevance 0
These data suggest that the upregulation of CXCL12 by seizures (Figure 4) in the adult hippocampus can increase migration of transplanted ESNPs along the septotemporal axis.
Positive_regulation (increase) of Positive_regulation (upregulation) of CXCL12 in hippocampus associated with convulsion and hippocampus
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.95 Pain Relevance 0.09
Tonic CXCL12 stimulation induces breakdown of focal adhesions
Positive_regulation (induces) of Positive_regulation (stimulation) of CXCL12 associated with adhesions
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.13 Pain Relevance 0.09
Several studies demonstrated that in these animals the thymus exhibits enhanced deposition of extracellular matrix proteins such as fibronectin, laminin, and type IV collagen, increased chemokine contents such as CXCL12, and expression of de-adhesive molecules such as galectin-3.
Positive_regulation (enhanced) of Positive_regulation (increased) of CXCL12 in thymus associated with chemokine
4) Confidence 0.18 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.27 Pain Relevance 0.05

General Comments

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