INT27437

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Context Info
Confidence 0.24
First Reported 1989
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.80
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
synovial fluid 1
plasma 1
cartilage 1
Comp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 216 99.80 Very High Very High Very High
rheumatoid arthritis 37 99.70 Very High Very High Very High
agonist 42 99.48 Very High Very High Very High
Arthritis 102 99.00 Very High Very High Very High
Osteoarthritis 7 93.76 High High
anesthesia 7 88.20 High High
Pain threshold 1 74.88 Quite High
gABA 16 63.00 Quite High
Nucleus accumbens 10 50.00 Quite Low
Inflammation 25 38.56 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 38 99.70 Very High Very High Very High
Arthritis 102 99.00 Very High Very High Very High
Disease 42 96.48 Very High Very High Very High
Knee Osteoarthritis 7 94.16 High High
Sprains And Strains 5 82.16 Quite High
Hypersensitivity 4 79.76 Quite High
Recurrence 1 78.00 Quite High
Pain 4 74.88 Quite High
Immunization 4 70.00 Quite High
Stress 1 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease in circulating COMP—a measurement of ongoing cartilage destruction [19]—occurred after treatment (Figure 5B).
Negative_regulation (decrease) of COMP in cartilage
1) Confidence 0.24 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.39 Pain Relevance 0.35
An increased level of COMP in the synovial fluid was described in the early stage of rheumatoid arthritis (RA), whereas in advanced stages of RA, the level of COMP decreased.
Negative_regulation (decreased) of COMP in synovial fluid associated with rheumatoid arthritis
2) Confidence 0.19 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15940561 Disease Relevance 1.15 Pain Relevance 0.49
In the group PA, plasma levels of Comp-beta, ACTH, E and NE were significantly decreased.
Negative_regulation (decreased) of Comp-beta in plasma
3) Confidence 0.15 Published 1989 Journal Agressologie Section Abstract Doc Link 2610292 Disease Relevance 0.27 Pain Relevance 0.63
Exponential extrapolation of the decay of Comp1 and subtraction to isolate Comp2 (labeled 2') revealed that DA markedly attenuated Comp1, with little effect on Comp2' (Figure 7B1).
Negative_regulation (attenuated) of Comp1 associated with dopamine
4) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.34
The D2 agonist Quinpirole significantly attenuated Comp1 while modestly facilitating Comp2' (Figure 7B3).
Negative_regulation (attenuated) of Comp1 associated with agonist
5) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.33

General Comments

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