INT274372

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.47
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) nucleus (Phc1)
DNA binding (Phc1) transmembrane transport (Slc6a3)
Anatomy Link Frequency
synapse 1
Phc1 (Mus musculus)
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 372 99.56 Very High Very High Very High
Neurotransmitter 32 91.48 High High
dopamine receptor 8 88.80 High High
agonist 4 87.28 High High
Eae 8 75.16 Quite High
Nucleus accumbens 24 70.80 Quite High
Action potential 4 70.16 Quite High
imagery 20 66.96 Quite High
noradrenaline 60 61.36 Quite High
Catecholamine 8 41.76 Quite Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 120 96.64 Very High Very High Very High
Cognitive Disorder 44 85.72 High High
Lumbar Puncture Related Headaches 4 29.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Volkow and colleagues [56] suggest that the therapeutical relevance of subcortical DAT blockade by MPH is based on two mechanisms.
MPH Negative_regulation (blockade) of DAT
1) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.16 Pain Relevance 0.55
Seeman and Madras [42, 43] suggest that the therapeutical relevance of subcortical DAT blockade by MPH is based on the drug’s biphasic action.
MPH Negative_regulation (blockade) of DAT
2) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.06 Pain Relevance 0.47
Therefore, MPH-induced blockade of the DAT increases dopamine concentrations in the synapse and extracellular space [56].
MPH Negative_regulation (blockade) of DAT in synapse associated with dopamine
3) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.15 Pain Relevance 0.45
Two hypotheses have been proposed to explain the clinical relevance of subcortical DAT blockade by MPH.
MPH Negative_regulation (blockade) of DAT
4) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701285 Disease Relevance 0.10 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox