INT27438

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Context Info
Confidence 0.51
First Reported 1986
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.24
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgds) transport (Ptgds) nuclear envelope (Ptgds)
extracellular space (Ptgds) extracellular region (Ptgds) Golgi apparatus (Ptgds)
Anatomy Link Frequency
brain 1
Ptgds (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 4 99.32 Very High Very High Very High
antagonist 7 99.20 Very High Very High Very High
tetrodotoxin 2 98.40 Very High Very High Very High
anesthesia 7 93.40 High High
Serotonin 4 93.16 High High
Intracerebroventricular 1 88.84 High High
Dopamine 2 85.64 High High
narcan 2 80.24 Quite High
Endogenous opioid 1 78.08 Quite High
Pain threshold 1 63.44 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 93.44 High High
Sprains And Strains 1 87.36 High High
Pain 1 63.44 Quite High
Stress 1 45.20 Quite Low
Shock 1 42.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the thromboxane A2 antagonist, SK&F 88046, concentration-dependently inhibited the PGD2 effect.
Negative_regulation (inhibited) of PGD2 associated with antagonist
1) Confidence 0.51 Published 1994 Journal Acta Physiol. Scand. Section Abstract Doc Link 8135127 Disease Relevance 0 Pain Relevance 0.23
The action of PGD2 was not inhibited but rather enhanced by the neurotoxin, tetrodotoxin, and by the PGD2 antagonist, AH 6809.
Negative_regulation (inhibited) of PGD2 associated with tetrodotoxin and antagonist
2) Confidence 0.42 Published 1994 Journal Acta Physiol. Scand. Section Abstract Doc Link 8135127 Disease Relevance 0 Pain Relevance 0.22
The antinociceptive action of centrally-administered PGD2 was markedly attenuated after pretreatment of the rats with 5,6-dihydroxytryptamine, a selective neurotoxin for central serotonergic neurones, and p-chlorophenylalanine, a specific inhibitor of serotonin synthesis, indicating that the PGD2 action is serotonin-mediated.
Negative_regulation (attenuated) of PGD2 associated with serotonin and antinociceptive
3) Confidence 0.37 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3016786 Disease Relevance 0.09 Pain Relevance 0.54
In the group of P.A. and E.A., PGD2 contents of the brain were decreased by 69.6% and 77.8% of the control group respectively.
Negative_regulation (decreased) of PGD2 in brain
4) Confidence 0.36 Published 1989 Journal Agressologie Section Abstract Doc Link 2610292 Disease Relevance 0.15 Pain Relevance 0.63

General Comments

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