INT274387

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (IGSF9) nucleoplasm (POLA1) nuclear envelope (POLA1)
DNA binding (POLA1) cytoplasm (POLA1) cell proliferation (POLA1)
POLA1 (Homo sapiens)
IGSF9 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 13 31.00 Quite Low
abdominal pain 6 30.20 Quite Low
antagonist 5 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 16 86.20 High High
Hyperlipidemia 4 80.96 Quite High
Flatulence 1 60.12 Quite High
Exanthema 19 59.48 Quite High
Diarrhoea 10 59.24 Quite High
Vomiting 17 58.84 Quite High
Renal Failure 2 57.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 129 50.00 Quite Low
Headache 13 31.00 Quite Low
Asthenia 3 30.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By binding noncompetitively to the hydrophobic pocket close to the polymerase catalytic site of the reverse transcriptase, NNRTIs decrease reverse transcriptase polymerizing activity.
polymerase catalytic site Binding (binding) of NRTI
1) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 0.58 Pain Relevance 0

General Comments

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