INT274405

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 25
Disease Relevance 6.51
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Zfpm2) intracellular (Zfpm2) DNA binding (Zfpm2)
nucleic acid binding transcription factor activity (Zfpm2) transcription factor binding (Zfpm2) cytoplasm (Zfpm2)
Anatomy Link Frequency
heart 4
fibroblasts 3
cardiomyocytes 2
myocardium 1
epicardium 1
Zfpm2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 25 5.00 Very Low Very Low Very Low
isoflurane 25 5.00 Very Low Very Low Very Low
imagery 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1000 96.72 Very High Very High Very High
Ventricular Heart Septal Defects 175 95.00 High High
Repression 200 93.12 High High
Hyperplasia 25 91.12 High High
Heart Defects 50 90.56 High High
Atrial Heart Septal Defects 25 84.80 Quite High
Cv General 4 Under Development 25 81.68 Quite High
Cytomegalovirus Infection 175 74.48 Quite High
Embryonic Lethality 75 53.68 Quite High
Disease 75 32.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this report, we demonstrate that FOG-2 expression is controlled at the translational level by microRNA-130a.
Gene_expression (expression) of FOG-2
1) Confidence 0.77 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2701631 Disease Relevance 0 Pain Relevance 0
Thus, expression of miR-130a and FOG-2 overlaps in the heart and lung and suggests that in these tissues miR-130a might modulate translation of the FOG-2 message.
Gene_expression (expression) of FOG-2 in heart
2) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0 Pain Relevance 0
FOG-2 mRNA is predominately expressed in the heart, brain, and gonads in the adult, with lower levels in liver and lung [22].
Gene_expression (expressed) of FOG-2 mRNA in gonads
3) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0 Pain Relevance 0
Due to the large number of miRNAs predicted to target the FOG-2 3?
Gene_expression (target) of FOG-2 3
4) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.13 Pain Relevance 0
UTR, we co-transfected COS-7 fibroblasts with our miR-130a expression vector and our FOG-2 UTR reporter.
Gene_expression (expression) of FOG-2 UTR reporter in fibroblasts
5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.13 Pain Relevance 0
We identified a conserved region in the FOG-2 3?
Gene_expression (region) of FOG-2 3
6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2701631 Disease Relevance 0 Pain Relevance 0
These results reveal that FOG-2 protein levels are also dynamically regulated during heart development, with peak levels occurring at embryonic day 16.5 and diminishing in the neonate.
Gene_expression (levels) of FOG-2 protein in heart
7) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0 Pain Relevance 0
The results demonstrate that fibroblasts transfected with the FOG-2 3?
Gene_expression (transfected) of FOG-2 3 in fibroblasts
8) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.07 Pain Relevance 0
Taken together with the loss of function experiments described above, these results demonstrate that miR-130a targets the FOG-2 3?
Gene_expression (targets) of FOG-2 3
9) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.36 Pain Relevance 0
-O-methyl oligonucleotide to specifically block miR-130a and co-transfected it along with our FOG-2 3?
Gene_expression (transfected) of FOG-2 3
10) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.23 Pain Relevance 0
Interestingly, as miR-130a levels peak in the neonate, FOG-2 protein levels decline (Fig. 1F).
Gene_expression (levels) of FOG-2 protein
11) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.06 Pain Relevance 0
These results support the hypothesis that translation of FOG-2 mRNA is regulated by miR-130a in cardiomyocytes in vivo.
Gene_expression (translation) of FOG-2 mRNA in cardiomyocytes
12) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.74 Pain Relevance 0
To demonstrate the effect of miR-130a overexpression on FOG-2 protein levels, we performed western analysis of ?
Gene_expression (levels) of FOG-2 protein
13) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.80 Pain Relevance 0
UTR, we co-transfected COS-7 fibroblasts with our miR-130a expression vector and our FOG-2 UTR reporter.
Gene_expression (transfected) of FOG-2 UTR reporter in fibroblasts
14) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.13 Pain Relevance 0
To test if expression of miR-130a would repress translation of our reporter construct containing the FOG-2 3?
Gene_expression (containing) of FOG-2 3
15) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.07 Pain Relevance 0
These results demonstrate the importance of miR-130a for the regulation of FOG-2 protein expression and suggest that miR-130a may also play a role in the regulation of cardiac development.



Gene_expression (expression) of FOG-2 protein
16) Confidence 0.59 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2701631 Disease Relevance 0.27 Pain Relevance 0
Though several factors may contribute to the dynamic pattern of FOG-2 protein expression during development, these results are consistent with the notion that miR-130a may play a role in regulating FOG-2 protein levels.


Gene_expression (expression) of FOG-2 protein
17) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.07 Pain Relevance 0
During cardiac development, FOG-2 is expressed in the myocardium, endocardium, and epicardium.
Gene_expression (expressed) of FOG-2 in epicardium
18) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.92 Pain Relevance 0
The loss of conservation of this site in the zebrafish FOG-2 genes may be explained by the lack of expression of these genes in the developing heart, in contrast to their orthologues in higher vertebrates.
Gene_expression (expression) of FOG-2 in heart
19) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.44 Pain Relevance 0
The results shown in figure 3D indicate a 2.9-fold increase in translation upon removal of the microRNA target site (p<0.0001), suggesting the importance of this site for translational regulation of FOG-2 expression in cardiomyocytes.
Gene_expression (expression) of FOG-2 in cardiomyocytes
20) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox