INT274418

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Zfpm2) intracellular (Zfpm2) DNA binding (Zfpm2)
nucleic acid binding transcription factor activity (Zfpm2) transcription factor binding (Zfpm2) cytoplasm (Zfpm2)
Anatomy Link Frequency
cardiomyocytes 2
heart 2
Zfpm2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 160 98.20 Very High Very High Very High
Ventricular Heart Septal Defects 28 95.56 Very High Very High Very High
Repression 32 93.12 High High
Embryonic Lethality 12 55.16 Quite High
Cytomegalovirus Infection 28 47.36 Quite Low
Cv General 4 Under Development 4 17.76 Low Low
Heart Defects 8 12.88 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Subacute Sclerosing Panencephalitis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results reveal that FOG-2 protein levels are also dynamically regulated during heart development, with peak levels occurring at embryonic day 16.5 and diminishing in the neonate.
Regulation (regulated) of Gene_expression (levels) of FOG-2 protein in heart
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0 Pain Relevance 0
To demonstrate the effect of miR-130a overexpression on FOG-2 protein levels, we performed western analysis of ?
Regulation (effect) of Gene_expression (levels) of FOG-2 protein
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.92 Pain Relevance 0
These results demonstrate the importance of miR-130a for the regulation of FOG-2 protein expression and suggest that miR-130a may also play a role in the regulation of cardiac development.



Regulation (regulation) of Gene_expression (expression) of FOG-2 protein
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2701631 Disease Relevance 0.27 Pain Relevance 0
The results shown in figure 3D indicate a 2.9-fold increase in translation upon removal of the microRNA target site (p<0.0001), suggesting the importance of this site for translational regulation of FOG-2 expression in cardiomyocytes.
Regulation (regulation) of Gene_expression (expression) of FOG-2 in cardiomyocytes
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701631 Disease Relevance 0.23 Pain Relevance 0

General Comments

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