INT274449

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 1
Cd4 (Mus musculus)
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 89.04 High High
Inflammation 12 56.64 Quite High
Spinal cord 2 30.92 Quite Low
Neuritis 1 29.24 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Glutamate receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 99.08 Very High Very High Very High
Sprains And Strains 10 96.04 Very High Very High Very High
Hematological Disease 18 84.32 Quite High
Immunization 6 76.56 Quite High
Multiple Sclerosis 3 72.44 Quite High
Demyelinating Disease 3 72.28 Quite High
Disease 7 69.96 Quite High
Neuromyelitis Optica 31 59.00 Quite High
INFLAMMATION 12 56.64 Quite High
Recurrence 6 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using triple transgenic mice, we are able to simulate the functional interaction between human CD4 and human MHC-II molecules.
CD4 Binding (interaction) of MHC-II associated with targeted disruption
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.57 Pain Relevance 0.04
In contrast to B cells and their secreted antibodies, which frequently recognize conformational determinants, Ag-specific CD4+ T cells recognize specific Ag determinants in association with MHC II molecules expressed on the cell surface of Ag presenting cells (APCs) [16].
CD4 Binding (recognize) of MHC II in T cells
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994828 Disease Relevance 0.68 Pain Relevance 0.05

General Comments

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