INT274471

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A, IL10) extracellular region (IL12A, IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10) cytoplasm (IL12A)
Anatomy Link Frequency
TAM 2
IL12A (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cOX1 3 72.68 Quite High
cytokine 12 60.72 Quite High
chemokine 3 59.92 Quite High
sodium channel 5 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 63 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 18 98.72 Very High Very High Very High
Adenocarcinoma 53 80.36 Quite High
Severe Combined Immunodeficiency 6 58.12 Quite High
Apoptosis 5 29.48 Quite Low
Lung Cancer 7 5.00 Very Low Very Low Very Low
Bronchiolo-alveolar Adenocarcinoma 5 5.00 Very Low Very Low Very Low
Carcinoma 4 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we show that IL-12 inhibits directly human NSCLC growth, and others [30] have demonstrated in mouse models that IL-12 alters the functional profile of tumor associated macrophages (TAM) by rapidly reducing production of IL-10, MCP-1/CCL2, migration inhibitory factor and TGF-?
IL-12 Negative_regulation (reducing) of Gene_expression (production) of IL-10 in TAM associated with cancer and non-small-cell lung cancer
1) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.99 Pain Relevance 0.10

General Comments

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