INT274527

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.68
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SYNM) cytoplasm (SYNM)
Anatomy Link Frequency
brain 1
SYNM (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 123 99.84 Very High Very High Very High
Pain 295 98.62 Very High Very High Very High
backache 12 98.24 Very High Very High Very High
Anterior cingulate cortex 24 96.36 Very High Very High Very High
Chronic low back pain 5 95.76 Very High Very High Very High
insula 28 94.76 High High
Spinal cord 8 94.08 High High
Thalamus 23 91.72 High High
Anterior cingulate 6 90.68 High High
amygdala 7 84.24 Quite High
Disease Link Frequency Relevance Heat
Pain 423 99.84 Very High Very High Very High
Low Back Pain 17 98.56 Very High Very High Very High
Nociception 12 96.36 Very High Very High Very High
Cognitive Disorder 31 92.56 High High
Urological Neuroanatomy 48 73.28 Quite High
Complex Regional Pain Syndromes 22 71.92 Quite High
Disease 24 69.96 Quite High
Depression 13 63.44 Quite High
Anxiety Disorder 8 62.32 Quite High
Amputation 2 43.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Baliki and colleagues [46] showed that the functional connectivity within the DMN is altered in patients that had suffered from chronic back pain for an average of 6 years.
Regulation (altered) of DMN associated with low back pain and backache
1) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 0.78 Pain Relevance 0.84
While these two studies report contradictory results in relation to the changes in DMN in chronic pain, it is important to note that brain reorganization is a plastic, time-dependent process that is initially driven by peripheral and spinal cord events, and subsequently by higher processing related to coping strategies [46].
Regulation (changes) of DMN in brain associated with lasting pain and spinal cord
2) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.00 Pain Relevance 1.01
Other studies show that activity in the DMN decreases in response to repeated painful stimuli [85], and chronic pain patients seem to exhibit permanently altered DMN activity.
Regulation (altered) of DMN associated with pain and lasting pain
3) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2993660 Disease Relevance 0.90 Pain Relevance 0.84

General Comments

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