INT27455

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Context Info
Confidence 0.60
First Reported 1982
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 4.30
Pain Relevance 3.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (C2)
Anatomy Link Frequency
dorsal 1
cell groups 1
cranial 1
Posterior 1
neurons 1
C2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
psoriasis 3 98.76 Very High Very High Very High
Pain 10 97.40 Very High Very High Very High
Thalamus 1 96.84 Very High Very High Very High
electroacupuncture 5 96.04 Very High Very High Very High
narcan 2 93.84 High High
halothane 1 92.32 High High
local anesthetic 1 91.88 High High
Potency 1 86.12 High High
Sumatriptan 6 85.96 High High
Clonidine 7 84.84 Quite High
Disease Link Frequency Relevance Heat
Eczema 6 100.00 Very High Very High Very High
Metastasis 2 99.96 Very High Very High Very High
Cough 21 99.72 Very High Very High Very High
Nociception 6 98.92 Very High Very High Very High
Psoriasis 3 98.76 Very High Very High Very High
Pain 7 97.40 Very High Very High Very High
Pressure And Volume Under Development 3 97.00 Very High Very High Very High
Nicotine Addiction 4 89.76 High High
Paralysis 1 83.92 Quite High
Injury 2 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the levels of C1 as well as those of C2 and C3 were markedly increased in the peripheral serum of day-21 rats within 15 min of LH administration.
Positive_regulation (increased) of C2
1) Confidence 0.60 Published 1984 Journal Endocrinology Section Abstract Doc Link 6697963 Disease Relevance 0.08 Pain Relevance 0.08
Direct stimulation of C2 produces an inhibition of nociceptive EP in the parafascicular complex of the thalamus.
Positive_regulation (stimulation) of C2 in thalamus associated with nociception and thalamus
2) Confidence 0.56 Published 1982 Journal Biull Eksp Biol Med Section Abstract Doc Link 7093467 Disease Relevance 0.38 Pain Relevance 0.49
On the basis of published models of enzyme binding, replacement of the C-2 hydroxyl group of bestatin by a sulfhydryl group was anticipated to lead to enhanced inhibition due to a strengthened interaction of this group with enzymic zinc.
Positive_regulation (replacement) of C-2
3) Confidence 0.49 Published 1988 Journal J. Med. Chem. Section Abstract Doc Link 3184127 Disease Relevance 0 Pain Relevance 0.16
Posterior stabilization of C2 metastases by combination of atlantoaxial screw fixation and hook plate.
Positive_regulation (stabilization) of C2 in Posterior associated with metastasis
4) Confidence 0.46 Published 1994 Journal Eur Spine J Section Title Doc Link 7874542 Disease Relevance 0.59 Pain Relevance 0.22
Subluxation of C2 was seen as a small, dorsally displaced opacity between the proximal and distal rows of carpal bones on the mediolateral view and, on the oblique view taken in only one case, as a marked dorsal displacement of one-third of the proximal joint surface of C2.
Positive_regulation (Subluxation) of C2 in dorsal
5) Confidence 0.46 Published 2001 Journal J Small Anim Pract Section Abstract Doc Link 11480904 Disease Relevance 0.36 Pain Relevance 0.09
Cough sensitivity (C2) in atopic dermatitis patients without clinical respiratory symptoms is significantly increased.
Positive_regulation (increased) of C2 in respiratory associated with eczema and cough
6) Confidence 0.41 Published 2003 Journal Pulm Pharmacol Ther Section Abstract Doc Link 12850122 Disease Relevance 1.43 Pain Relevance 0.48
Studies of pain-producing intracranial structures, such as the superior sagittal sinus, have demonstrated that second order neurons as caudal as C2 are activated after either electrical or mechanical stimulation.
Positive_regulation (activated) of C2 in neurons associated with pain
7) Confidence 0.40 Published 1997 Journal Pain Section Abstract Doc Link 9414053 Disease Relevance 0.43 Pain Relevance 0.43
The concentrations of capsaicin that triggered two and five coughs, C2 and C5 respectively, were recorded.
Positive_regulation (triggered) of C2
8) Confidence 0.40 Published 2001 Journal Arch. Bronconeumol. Section Body Doc Link 11412528 Disease Relevance 0.09 Pain Relevance 0
In CS group, log C1 and log C2 remained increased up to 4 h after SA.
Positive_regulation (increased) of C2
9) Confidence 0.40 Published 2007 Journal Br J Anaesth Section Body Doc Link 17711983 Disease Relevance 0 Pain Relevance 0
Exercise duration of A2, B2, and C2 increased similarly compared with A1 (P=0.009).
Positive_regulation (increased) of C2
10) Confidence 0.24 Published 2003 Journal Circulation Section Body Doc Link 12665486 Disease Relevance 0.15 Pain Relevance 0
The blocking of protein synthesis by cycloheximide (CHX) evokes a further increase of C2 ceramide-induced proENK mRNA and phospho-CREB level, while C2 ceramide-induced increases of AP-1 protein levels were reduced by CHX.
Positive_regulation (increase) of C2
11) Confidence 0.23 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0
The blocking of protein synthesis by cycloheximide (CHX) evokes a further increase of C2 ceramide-induced proENK mRNA and phospho-CREB level, while C2 ceramide-induced increases of AP-1 protein levels were reduced by CHX.
Positive_regulation (increases) of C2
12) Confidence 0.20 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0
C2 was located cranial, ventral, and to the right of C1, while C3 was visualized as a tubular structure to the right and ventral to C1 and C2, C3 was traced caudally until it turned dorsally and continued cranially to a dilated ampulla in the right cranial abdomen delineating the entrance to the small intestine.
Positive_regulation (traced) of C2 in ventral
13) Confidence 0.18 Published 1998 Journal Vet Radiol Ultrasound Section Abstract Doc Link 9548138 Disease Relevance 0.24 Pain Relevance 0.13
Using an incremental capsaicin concentration challenge protocol, we recorded the concentrations that induced 2 (C2) and 5 or more coughs (C5).
Positive_regulation (induced) of C2
14) Confidence 0.16 Published 2009 Journal Respir Med Section Body Doc Link 19136241 Disease Relevance 0.17 Pain Relevance 0
C2 was located cranial, ventral, and to the right of C1, while C3 was visualized as a tubular structure to the right and ventral to C1 and C2, C3 was traced caudally until it turned dorsally and continued cranially to a dilated ampulla in the right cranial abdomen delineating the entrance to the small intestine.
Positive_regulation (traced) of C2 in cranial
15) Confidence 0.06 Published 1998 Journal Vet Radiol Ultrasound Section Abstract Doc Link 9548138 Disease Relevance 0.24 Pain Relevance 0.13
Electrical stimulation of the A1 or A2 region evoked excitatory responses from the majority of cells tested (76% and 85%, respectively), whilst stimulation of the A6 and C2 regions evoked more inhibitory responses (43% and 59%, respectively).
Positive_regulation (stimulation) of C2
16) Confidence 0.06 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2611683 Disease Relevance 0.08 Pain Relevance 0.13
This observation is consistent with former studies showing that the NR1 splice variant containing the C2-cassette is the predominant version of the two alternative carboxy-terminal isoforms NR1-C2 and NR1-C2?
Positive_regulation (isoforms) of C2
17) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.03
A obvious reduction of MAP appeared in the groups of C1 and C2, but in the other groups the hemodynamical parameters were stable.
Spec (appeared) Positive_regulation (groups) of C2
18) Confidence 0.06 Published 1997 Journal J. Tongji Med. Univ. Section Abstract Doc Link 9812772 Disease Relevance 0 Pain Relevance 1.44
Effects of stimulation of A1, A2, A6 and C2 cell groups.
Positive_regulation (stimulation) of C2 in cell groups
19) Confidence 0.05 Published 1989 Journal Brain Res. Bull. Section Title Doc Link 2611683 Disease Relevance 0.06 Pain Relevance 0.10

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