INT274553

Context Info Confidence 0.13 First Reported 2009 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.19 Pain Relevance 0.05

cytosol (MEFV, PSTPIP1, PYCARD) cytoplasm (MEFV, PSTPIP1, PYCARD) signal transduction (PSTPIP1, PYCARD) cytoskeleton (MEFV, PSTPIP1) intracellular (MEFV, PYCARD) oxidoreductase activity (PSTPIP1)

MEFV (Homo sapiens) PSTPIP1 (Homo sapiens) PYCARD (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 9 95.56 Pain 2 5.00 Arthritis 2 5.00

Disease Link Frequency Relevance Heat Disease 10 95.88 INFLAMMATION 9 95.56 Syndrome 9 10.24 Fever 11 5.00 Osteomyelitis 4 5.00 Pain 2 5.00 Arthritis 2 5.00 Acne 2 5.00 Pyoderma Gangrenosum 2 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A second difference between our findings and those of earlier studies is that we find that pyrin is not sequestered away from ASC by its interaction by PSTPIP1, and does not require PSTPIP1 to interact with ASC.

pyrin Neg (not) Positive_regulation (require) of PSTPIP1 Binding (interact) of ASC

1) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

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