INT274567

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Context Info
Confidence 0.46
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV, PSTPIP1) cytoskeleton (MEFV, PSTPIP1) cytoplasm (MEFV, PSTPIP1)
signal transduction (PSTPIP1) oxidoreductase activity (PSTPIP1) cell adhesion (PSTPIP1)
MEFV (Homo sapiens)
PSTPIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 73.96 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 20 74.28 Quite High
INFLAMMATION 18 73.96 Quite High
Syndrome 18 72.00 Quite High
Fever 22 5.00 Very Low Very Low Very Low
Osteomyelitis 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Acne 4 5.00 Very Low Very Low Very Low
Pyoderma Gangrenosum 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The model also suggests that the coherent convex binding surface would likely interact with both pyrin and the PEST phosphatases, since these PSTPIP1 mutations have been shown to reduce binding affinity for PEST phosphatases and increase affinity for pyrin (Shoham, 2005).


Positive_regulation (increase) of pyrin Binding (affinity) of PSTPIP1
1) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.07 Pain Relevance 0
Mutant PSTPIP1, by virtue of its increased binding affinity for pyrin, may be somewhat more readily recruited to ASC specks than is wild type PSTPIP1, placing mutant PSTPIP1 more frequently in the inflammasome compartment.
Positive_regulation (increased) of pyrin Binding (affinity) of Mutant PSTPIP1
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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