INT274569

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSTPIP2, PSTPIP1) cytoskeleton (PSTPIP2, PSTPIP1) cytoplasm (PSTPIP2, PSTPIP1)
signal transduction (PSTPIP1) oxidoreductase activity (PSTPIP1) cell adhesion (PSTPIP1)
Anatomy Link Frequency
filaments 1
SH3 1
PSTPIP2 (Homo sapiens)
PSTPIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 99.04 Very High Very High Very High
Arthritis 8 63.68 Quite High
Pain 8 41.08 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.04 Very High Very High Very High
Osteomyelitis 16 95.80 Very High Very High Very High
Syndrome 36 95.36 Very High Very High Very High
Disease 40 90.96 High High
Acne 8 64.96 Quite High
Pyoderma Gangrenosum 8 64.56 Quite High
Arthritis 8 63.68 Quite High
Pain 8 41.08 Quite Low
Fever 44 39.52 Quite Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings, it is tempting to speculate that the PSTPIP1-related protein, PSTPIP2, which lacks an SH3 domain, but also forms filaments in cells, might also interact with pyrin; PSTPIP2 has already been shown to interact with PEST phosphatases [8].
PSTPIP2 Binding (interact) of PEST in filaments
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.18 Pain Relevance 0.05
It is interesting to speculate that a similar model could also apply to the PSTPIP1-related protein, PSTPIP2.
PSTPIP2 Binding (apply) of PSTPIP1-related
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.24 Pain Relevance 0.04
PSTPIP1, but not PSTPIP2, also contains a C-terminal SH3 domain that is important for the binding of several PEST phosphatase substrates, including c-abl and WASP [8], [14].
PSTPIP2 Binding (binding) of PEST in SH3
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.79 Pain Relevance 0.11
PSTPIP1 and PSTPIP2 share an N-terminal Fer-CIP4 homology (FCH) domain and a central coiled-coil region, through which they bind to PEST-type phosphatases [12], [13].
PSTPIP2 Binding (bind) of PEST
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.86 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox