INT274577

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MEFV, SASH3) cytoplasm (MEFV, SASH3) cytosol (MEFV)
cytoskeleton (MEFV) intracellular (MEFV)
Anatomy Link Frequency
SH3 2
filaments 1
MEFV (Homo sapiens)
SASH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 87.68 High High
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 87.68 High High
Disease 30 86.64 High High
Fever 33 79.60 Quite High
Syndrome 27 75.32 Quite High
Osteomyelitis 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Acne 6 5.00 Very Low Very Low Very Low
Pyoderma Gangrenosum 6 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings, it is tempting to speculate that the PSTPIP1-related protein, PSTPIP2, which lacks an SH3 domain, but also forms filaments in cells, might also interact with pyrin; PSTPIP2 has already been shown to interact with PEST phosphatases [8].
pyrin Spec (might) Binding (interact) of SH3 in filaments
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.17 Pain Relevance 0.04
Thus, the SH3 domain is apparently dispensable for the interaction between pyrin and PSTPIP1.
pyrin Binding (interaction) of SH3 in SH3
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
We also examine the pyrin/PSTPIP1 interaction and show that contrary to earlier predictions [5], the PSTPIP1 SH3 domain is not required for its interaction with pyrin.
pyrin Binding (interaction) of SH3 in SH3
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.27 Pain Relevance 0

General Comments

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