INT274593

Context Info Confidence 0.43 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.05 Pain Relevance 0

cytosol (PSTPIP1) signal transduction (PSTPIP1) oxidoreductase activity (PSTPIP1) cell adhesion (PSTPIP1) cytoskeleton (PSTPIP1) cytoplasm (PSTPIP1)

Anatomy Link Frequency filaments 2 PSTPIP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 18 5.00 Pain 4 5.00 Arthritis 4 5.00

Disease Link Frequency Relevance Heat Disease 20 50.24 Fever 22 15.52 Syndrome 18 5.00 INFLAMMATION 18 5.00 Osteomyelitis 8 5.00 Pain 4 5.00 Arthritis 4 5.00 Acne 4 5.00 Pyoderma Gangrenosum 4 5.00 Adhesions 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Modeling PSTPIP1 structure: prediction of separate membrane-interacting and pyrin-interacting surfaces

Negative_regulation (prediction) of Gene_expression (structure) of PSTPIP1

1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.05 Pain Relevance 0

Note also that PSTPIP1 filaments, in the absence of pyrin decoration, are finer and more delicate in nature (compare Figure 4G to Figure 4J)

Negative_regulation (finer) of Gene_expression (filaments) of PSTPIP1 in filaments

2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.