INT274606

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV) cytoskeleton (MEFV) nucleus (MEFV)
intracellular (MEFV) cytoplasm (MEFV)
Anatomy Link Frequency
filaments 2
MEFV (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 77.76 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 77.76 Quite High
Fever 22 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Syndrome 18 5.00 Very Low Very Low Very Low
Osteomyelitis 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Acne 4 5.00 Very Low Very Low Very Low
Pyoderma Gangrenosum 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the W232A mutation in PSTPIP1 abolished pyrin binding; consequently, PSTPIP1 filaments were primarily straight, not extensively branched (Figure 4I–K), confirming that the reticularization of PSTPIP1 filaments is a direct consequence of pyrin binding.
Negative_regulation (abolished) of pyrin Binding (binding) of in filaments
1) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
The pyrin homotrimer, they propose, is autoinhibited by the association of its pyrin domain (PyD) with its own B-box.
Negative_regulation (autoinhibited) of pyrin Binding (association) of
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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