INT274609

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSTPIP1) signal transduction (PSTPIP1) oxidoreductase activity (PSTPIP1)
cell adhesion (PSTPIP1) cytoskeleton (PSTPIP1) cytoplasm (PSTPIP1)
Anatomy Link Frequency
filaments 2
PSTPIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 27 86.36 High High
Disease 30 77.76 Quite High
Fever 33 73.96 Quite High
INFLAMMATION 27 5.00 Very Low Very Low Very Low
Osteomyelitis 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Acne 6 5.00 Very Low Very Low Very Low
Pyoderma Gangrenosum 6 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To explore the effect of PAPA mutations on the PSTPIP1:pyrin interaction, we next tested whether the filaments formed by mutant forms of PSTPIP1 could be reorganized by pyrin.
Regulation (effect) of PSTPIP1 Binding (interaction) of in filaments
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.15 Pain Relevance 0
Similarly, in previous studies using immunoprecipitation, mutations in pyrin did not modify its interaction with PSTPIP1 [5].
Neg (not) Regulation (modify) of PSTPIP1 Neg (not) Binding (interaction) of
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.15 Pain Relevance 0
This corroborates earlier reports that mutant forms of PSTPIP1 bind to pyrin with higher affinity [5], and confirms that PSTPIP1 recruitment to the speck compartment depends on the PSTPIP1-pyrin interaction.
Regulation (depends) of PSTPIP1 Binding (recruitment) of
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.14 Pain Relevance 0

General Comments

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