INT274614

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.33
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSTPIP2) cytoskeleton (PSTPIP2) cytoplasm (PSTPIP2)
Anatomy Link Frequency
filaments 2
PSTPIP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 86.80 High High
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 86.80 High High
Disease 30 85.76 High High
Osteomyelitis 12 29.44 Quite Low
Fever 33 5.00 Very Low Very Low Very Low
Syndrome 27 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Acne 6 5.00 Very Low Very Low Very Low
Pyoderma Gangrenosum 6 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings, it is tempting to speculate that the PSTPIP1-related protein, PSTPIP2, which lacks an SH3 domain, but also forms filaments in cells, might also interact with pyrin; PSTPIP2 has already been shown to interact with PEST phosphatases [8].
PSTPIP2 Spec (might) Binding (interact) of in filaments
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.17 Pain Relevance 0.04
Indeed, the F-BAR domains of both PSTPIP1 and PSTPIP2 can bind to artificial liposomes containing phosphatidyl inositol (4,5) bisphosphate (PI(4,5)P2) with high affinity [19].
PSTPIP2 Binding (bind) of
2) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Based on these findings, it is tempting to speculate that the PSTPIP1-related protein, PSTPIP2, which lacks an SH3 domain, but also forms filaments in cells, might also interact with pyrin; PSTPIP2 has already been shown to interact with PEST phosphatases [8].
PSTPIP2 Neg (lacks) Binding (lacks) of in filaments
3) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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