INT274619

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.27
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV) cytoskeleton (MEFV) nucleus (MEFV)
intracellular (MEFV) cytoplasm (MEFV)
Anatomy Link Frequency
filaments 6
MEFV (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 67.36 Quite High
Pain 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 44 83.28 Quite High
INFLAMMATION 36 67.36 Quite High
Disease 40 57.00 Quite High
Syndrome 36 28.64 Quite Low
Osteomyelitis 16 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Acne 8 5.00 Very Low Very Low Very Low
Pyoderma Gangrenosum 8 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pyrin expression alters PSTPIP1 distribution
Regulation (alters) of Gene_expression (expression) of Pyrin
1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Note also that PSTPIP1 filaments, in the absence of pyrin decoration, are finer and more delicate in nature (compare Figure 4G to Figure 4J)
Regulation (absence) of Gene_expression (decoration) of pyrin in filaments
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
Mutations in pyrin or PSTPIP1 do not alter the pattern of PSTPIP1 filaments
Neg (not) Regulation (alter) of Gene_expression (Mutations) of pyrin in filaments
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.08 Pain Relevance 0
We were not able to discern an effect of either pyrin mutations or PSTPIP1 mutations on the property of PSTPIP1 filament reticularization.
Regulation (effect) of Gene_expression (mutations) of pyrin in filament
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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