INT27465

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 8.09
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
Anatomy Link Frequency
plasma 5
chest 2
macrophages 1
endothelial cells 1
umbilical vein 1
F12 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 24 99.96 Very High Very High Very High
bradykinin 35 99.90 Very High Very High Very High
Inflammation 22 98.28 Very High Very High Very High
Angina 12 97.48 Very High Very High Very High
Analgesic 2 95.84 Very High Very High Very High
cINOD 3 93.68 High High
cva 19 93.28 High High
Serotonin 1 81.68 Quite High
algogenic 1 68.80 Quite High
ischemia 5 32.32 Quite Low
Disease Link Frequency Relevance Heat
Pain 20 99.96 Very High Very High Very High
Coagulation Disorder 30 98.88 Very High Very High Very High
INFLAMMATION 25 98.28 Very High Very High Very High
Angina 5 97.48 Very High Very High Very High
Pressure Volume 2 Under Development 19 97.24 Very High Very High Very High
Thrombosis 129 97.20 Very High Very High Very High
Hematoma 37 96.92 Very High Very High Very High
Coronary Artery Disease 18 96.92 Very High Very High Very High
Cv General 3 Under Development 16 93.28 High High
Increased Venous Pressure Under Development 3 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a complete evaluation of all these properties of FXII and FXIIa has to be considered when formulating a strategy for blocking FXII activation.
Positive_regulation (activation) of FXII
1) Confidence 0.70 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.55 Pain Relevance 0.17
The target mentioned above may either be an inhibition of FXII activation or an inhibition of its proteolytic activity.
Positive_regulation (activation) of FXII
2) Confidence 0.70 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 17996217 Disease Relevance 0.67 Pain Relevance 0.15
This indicates that the factor XII Tenri present in disulfide-linked complexes with other proteins (and itself) is not converted to active forms, suggesting that attached proteins obstruct or delay the activation of factor XII via an inhibition of its binding to a negatively charged surface in vitro.
Positive_regulation (activation) of factor XII
3) Confidence 0.66 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15228238 Disease Relevance 0.05 Pain Relevance 0.05
Increased FXII zymogen levels have primarily been associated with a decrease in risk for MI and outcome [29,31].
Positive_regulation (Increased) of FXII
4) Confidence 0.56 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 0.99 Pain Relevance 0.07
Kaolin thus induces a clear and reproducible writing reaction, which might be mainly dependent on the action of bradykinin via activation of factor XII, and should prove to be a simple and convenient model of bradykinin-induced pain for the assessment of analgesic actions.
Positive_regulation (activation) of factor XII associated with pain, analgesic and bradykinin
5) Confidence 0.54 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2668495 Disease Relevance 0.25 Pain Relevance 0.40
Glucocorticoids prevent activation of factor XII by endotoxin in vivo and decrease production of tissue factor by macrophages.
Positive_regulation (activation) of factor XII in macrophages
6) Confidence 0.51 Published 1983 Journal Agents Actions Section Abstract Doc Link 6356816 Disease Relevance 0.23 Pain Relevance 0.23
A new writhing model of factor XII activator-induced pain for assessment of non-steroidal anti-inflammatory agents.
Positive_regulation (activator-induced) of factor XII associated with pain and inflammation
7) Confidence 0.39 Published 1989 Journal J. Pharmacobio-dyn. Section Title Doc Link 2668495 Disease Relevance 0.20 Pain Relevance 0.37
Contact activation, believed to be potentiated by negatively charged surfaces, results in the activation of the zymogen FXII to FXIIa and affects several pathophysiological processes including hypotension, inflammation, thrombosis and fibrinolysis[13-20].
Positive_regulation (activation) of FXII associated with pressure volume 2 under development, inflammation and thrombosis
8) Confidence 0.38 Published 2010 Journal Thromb J Section Body Doc Link PMC2871266 Disease Relevance 1.63 Pain Relevance 0.09
This short-lived peptide hormone is liberated from its large precursor protein high molecular weight kininogen (HK) through the contact system cascade involving coagulation factor XII and plasma kallikrein.
Positive_regulation (involving) of factor XII in plasma
9) Confidence 0.26 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16116231 Disease Relevance 0.28 Pain Relevance 0.39
A mechanism of writhing reaction induced by kaolin, a known activator of factor XII, was studied.
Positive_regulation (activator) of factor XII
10) Confidence 0.25 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2614639 Disease Relevance 0 Pain Relevance 0
Factor XII (FXII) and high molecular weight kininogen (HK), two critical constituents of the plasma K-K cascade, bind to endothelial cells, and bound FXII is autoactivated in the presence of zinc ions.
Positive_regulation (autoactivated) of FXII in endothelial cells
11) Confidence 0.20 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.26 Pain Relevance 0.22
Neurotropin inhibited the binding of both proteins to cultured human umbilical vein endothelial cells (HUVEC) and inhibited autoactivation of FXII upon HUVEC in a concentration-dependent manner.
Positive_regulation (autoactivation) of FXII in umbilical vein
12) Confidence 0.14 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9719471 Disease Relevance 0.23 Pain Relevance 0.24
The conversion of plasma prekallikrein to kallikrein by the activated FXII and in response to numerous different stimuli leads to the generation of bradykinin (BK) and activated HK (HKa, an antiangiogenic peptide).
Positive_regulation (activated) of FXII in plasma associated with bradykinin
13) Confidence 0.13 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.33 Pain Relevance 0.40
Based on these findings, it was suggested that the FXII Thr309Lys mutation (referred to as Thr328Lys by adding the leader protein) is a gain-of-function mutation that markedly increases FXII amidolytic activity but that does not alter FXII plasma levels [6].
Positive_regulation (increases) of FXII in plasma
14) Confidence 0.06 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 0.29 Pain Relevance 0
CONCLUSION: XIIaA, a recently identified in vivo form of activated factor XII is an independent indicator of long-term all-cause mortality in patients admitted with chest pain, providing prognostic information above and beyond conventional risk factors.


Positive_regulation (activated) of factor XII in chest
15) Confidence 0.02 Published 2009 Journal J. Thromb. Haemost. Section Body Doc Link 19054318 Disease Relevance 0.05 Pain Relevance 0
Activated factor XII type A predicts long-term mortality in patients admitted with chest pain.
Positive_regulation (Activated) of factor XII in chest associated with angina
16) Confidence 0.02 Published 2009 Journal J. Thromb. Haemost. Section Title Doc Link 19054318 Disease Relevance 0.10 Pain Relevance 0.10
Secondly, in humans extracorporeal clotting during dialysis for example can occur independently of activation of factor XII, which was measured in the study by Krouzecky and colleagues.
Positive_regulation (activation) of factor XII associated with coagulation disorder
17) Confidence 0.02 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2820226 Disease Relevance 0.55 Pain Relevance 0
BACKGROUND: We assessed the relation between admission levels of activated factor XII type A (XIIaA), and long-term all-cause and cardiac mortality and recurrent troponin T (TnT) positive cardiovascular events in a consecutive cohort of 870 patients admitted with a clinically strongly suspected acute coronary syndrome (ACS).
Positive_regulation (activated) of factor XII associated with acute coronary syndrome
18) Confidence 0.02 Published 2009 Journal J. Thromb. Haemost. Section Abstract Doc Link 19054318 Disease Relevance 0.17 Pain Relevance 0.07
In patients with unstable angina pectoris, initially the contact phase and the kallikrein-kinin system were markedly elevated (factor XII, 96 +/- 5% versus 117 +/- 5%; kallikrein-like activity, 35.7 +/- 2.9 versus 27.4 +/- 1.3 U/L; high molecular weight kininogen, 52.7 +/- 5.2% versus 87.7 +/- 3.9%; P < .01 versus control subjects).
Positive_regulation (elevated) of factor XII
19) Confidence 0.01 Published 1995 Journal Circulation Section Body Doc Link 7743613 Disease Relevance 0.13 Pain Relevance 0
The D7 protein named hamadarin from Anopheles stephensi acts as an anticoagulant affecting the plasma contact system by inhibiting the activation of Factor XII and kallikrein [23].
Positive_regulation (activation) of Factor XII in plasma
20) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1434747 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox