INT27466

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Context Info
Confidence 0.10
First Reported 1984
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 7.79
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kng1) extracellular region (Kng1)
Anatomy Link Frequency
plasma 3
nerve 1
Kng1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 17 99.92 Very High Very High Very High
Hyperalgesia 4 99.32 Very High Very High Very High
Inflammation 177 99.12 Very High Very High Very High
bradykinin 50 98.12 Very High Very High Very High
Arthritis 78 95.08 Very High Very High Very High
b2 receptor 2 91.12 High High
Crohn's disease 3 87.84 High High
chemokine 2 82.08 Quite High
cytokine 12 81.60 Quite High
Pain 12 79.68 Quite High
Disease Link Frequency Relevance Heat
Coagulation Disorder 11 100.00 Very High Very High Very High
Hyperalgesia 4 99.32 Very High Very High Very High
INFLAMMATION 146 99.12 Very High Very High Very High
Adhesions 8 99.04 Very High Very High Very High
Nervous System Injury 4 99.00 Very High Very High Very High
Enterocolitis 9 98.76 Very High Very High Very High
Pleurisy 3 98.16 Very High Very High Very High
Toxicity 12 97.80 Very High Very High Very High
Sepsis 3 97.20 Very High Very High Very High
Burns 1 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B/N-Katholiek rats, which congenitally lack plasma kininogen and release no kinin, were also tested for hyperalgesic parameters.
Negative_regulation (lack) of kininogen in plasma
1) Confidence 0.10 Published 2003 Journal Inflamm. Res. Section Body Doc Link 12755382 Disease Relevance 0.14 Pain Relevance 0
Bradykinin played a role in plasma exudation in the pleurisy, because the plasma leakage was markedly inhibited in the rats, in which prekallikrein and HMW kininogen in plasma were depleted by intravenous bromelain.
Negative_regulation (depleted) of HMW kininogen in plasma associated with pleurisy and bradykinin
2) Confidence 0.09 Published 1986 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3812104 Disease Relevance 0.66 Pain Relevance 0.67
These results suggest that bromelain could deplete the HMW-kininogen in mouse plasma in the same way as in rat plasma.
Negative_regulation (deplete) of HMW-kininogen in plasma
3) Confidence 0.09 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2614639 Disease Relevance 0 Pain Relevance 0.04
Amelioration of hyperalgesia by kinin receptor antagonists or kininogen deficiency in chronic constriction nerve injury in rats.
Negative_regulation (deficiency) of kininogen in nerve associated with coagulation disorder, hyperalgesia, nervous system injury and antagonist
4) Confidence 0.09 Published 2003 Journal Inflamm. Res. Section Title Doc Link 12755382 Disease Relevance 0.30 Pain Relevance 0.38
The activity of WAY-169916 is related to its ability to suppress inflammatory processes globally, as demonstrated by the decrease in serum acute-phase protein levels of haptoglobin, ?
Negative_regulation (decrease) of acute-phase protein associated with inflammation
5) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 1.15 Pain Relevance 0.51
Kininogen deficiency is rare in humans and is not really an applicable therapeutic modality.
Negative_regulation (deficiency) of Kininogen associated with coagulation disorder
6) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175023 Disease Relevance 1.52 Pain Relevance 0.48
Third, kininogen deficiency was first described in Brown Norway rats [45].
Negative_regulation (deficiency) of kininogen associated with coagulation disorder
7) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175023 Disease Relevance 1.66 Pain Relevance 0.62
We introduced this mutation into a Lewis genetic background with five generations of backcrosses and showed that the deficiency of kininogen ameliorated acute and chronic enterocolitis [46].
Negative_regulation (deficiency) of kininogen associated with enterocolitis
8) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175023 Disease Relevance 1.57 Pain Relevance 0.60
Two studies of experimental endotoxemia in burns patients, septicemia and septic shock have demonstrated the following facts: activation occurs of specific ( pKK ) and non-specific (plasminogen-plasmin system) kininogenases , K-HMW and K-LMW levels are significantly decreased.
Negative_regulation (decreased) of K-HMW associated with endotoxemia, burns and sepsis
9) Confidence 0.03 Published 1984 Journal Ann. Biol. Clin. (Paris) Section Abstract Doc Link 6233919 Disease Relevance 0.79 Pain Relevance 0.25

General Comments

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