INT274681

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
osteoclasts 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 33 95.68 Very High Very High Very High
rheumatoid arthritis 30 86.12 High High
Inflammation 14 72.28 Quite High
metalloproteinase 7 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 4 96.40 Very High Very High Very High
Arthritis 34 95.68 Very High Very High Very High
Rheumatoid Arthritis 30 86.12 High High
Apoptosis 27 85.12 High High
Severe Combined Immunodeficiency 14 81.72 Quite High
Osteoporosis 4 81.56 Quite High
INFLAMMATION 14 72.28 Quite High
Disease 8 34.84 Quite Low
Cancer 1 32.48 Quite Low
Osteogenesis Imperfecta 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many studies demonstrate a direct role for collagen degradation in activation of osteoclasts and any reduction in collagenase-3 would result in impaired bone resorption (reviewed in [27]) contributing to the changes observed in the present study.
Positive_regulation (role) of Protein_catabolism (degradation) of collagen in osteoclasts associated with hypercalcemia
1) Confidence 0.05 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2703200 Disease Relevance 0.40 Pain Relevance 0
Cleaved fragments of collagen type II again can further induce MMP-13 gene expression and result in a cycle of collagen degradation.
Positive_regulation (result) of Protein_catabolism (degradation) of collagen
2) Confidence 0.01 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.78 Pain Relevance 0.28

General Comments

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