INT274693

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.93
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
lung 4
epithelial cells 2
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 241 98.68 Very High Very High Very High
Inflammation 66 85.04 High High
anesthesia 3 52.24 Quite High
agonist 5 29.20 Quite Low
cytokine 9 22.12 Low Low
aspirin 30 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 22 99.50 Very High Very High Very High
Non-genital Cutaneous Warts 2 99.48 Very High Very High Very High
Stress 3 99.38 Very High Very High Very High
Cystic Fibrosis 241 98.68 Very High Very High Very High
Sprains And Strains 18 96.64 Very High Very High Very High
INFLAMMATION 45 85.04 High High
Disorder Of Lipid Metabolism 36 84.08 Quite High
Insulin Resistance 3 81.68 Quite High
Infection 29 78.48 Quite High
Vibrio Infection 26 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes observed in the presence of the inhibitor were, however, less pronounced than those induced by CFTR deletion, thereby suggesting that blocking chloride conductance is one of the prerequisites for perturbations of intestinal FA metabolism.
Positive_regulation (induced) of Gene_expression (deletion) of CFTR
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.23 Pain Relevance 0.03
The most striking observation, in response to CFTR knockdown, was the downregulation of LXR-?
Positive_regulation (response) of Gene_expression (knockdown) of CFTR
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.15 Pain Relevance 0.07
-oxidation or lipid peroxidation as a consequence of oxidative stress, altered desaturase activity, enhanced production of eicosanoids and defective CFTR.
Positive_regulation (enhanced) of Gene_expression (production) of CFTR associated with stress
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.43 Pain Relevance 0.12
Although LPS challenge induced an increased COX-2 expression in lung tissues of CFTR-/- and CFTR +/+ mice, no significant differences were observed between these mouse strains neither before nor after LPS challenge (Figure 4B).


Positive_regulation (induced) of Gene_expression (expression) of CFTR in lung associated with sprains and strains
4) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.43 Pain Relevance 0.06
Enhanced airway constriction in LPS-treated CFTR -/- mice
Positive_regulation (Enhanced) of Gene_expression (constriction) of CFTR
5) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.09 Pain Relevance 0.09
Although LPS challenge induced an increased COX-2 expression in lung tissues of CFTR-/- and CFTR +/+ mice, no significant differences were observed between these mouse strains neither before nor after LPS challenge (Figure 4B).


Positive_regulation (increased) of Gene_expression (expression) of CFTR in lung associated with sprains and strains
6) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.43 Pain Relevance 0.06
Abnormalities in sialylation of cells transfected with mutant CFTR and secretions of patients with CF have been described [9]; however, it has not been clear whether this phenomenon has been directly mediated by the presence of neuraminidases in colonizing bacteria or by the abnormal CFTR.
Positive_regulation (transfected) of Gene_expression (transfected) of CFTR associated with fibrosis and congenital anomalies
7) Confidence 0.36 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2703207 Disease Relevance 0.92 Pain Relevance 0.33
Mouse mammary C127 epithelial cells, which do not express detectable levels of CFTR [15], transfected with bovine papilloma-based vector containing CFTR cDNA (WT), a CFTR cDNA with the ?
Positive_regulation (transfected) of Neg (not) Gene_expression (express) of CFTR in epithelial cells associated with non-genital cutaneous warts
8) Confidence 0.34 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2703207 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

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