INT274716

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TBL1XR1) small molecule metabolic process (TBL1XR1) histone binding (TBL1XR1)
DNA binding (TBL1XR1) peptidase activity (MMP1) extracellular region (MMP1)
Anatomy Link Frequency
fibroblasts 2
skin 2
TBL1XR1 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 9 39.04 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 24 100.00 Very High Very High Very High
Wrinkles 21 54.40 Quite High
Aging 9 25.00 Low Low
Shock 9 5.00 Very Low Very Low Very Low
Wound Healing 9 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Erythema 6 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, repeated exposure of human skin fibroblasts to wIRA(+RL) did not induce MMP-1 mRNA expression systematically (less than twofold expression by up to 10 consecutive wIRA(+RL) exposures and analysis with real-time RT-PCR).
wIRA Positive_regulation (induce) of Gene_expression (expression) of MMP-1 mRNA in skin
1) Confidence 0.02 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.23 Pain Relevance 0
On the molecular level, a recent publication has indicated that wIRA irradiation could induce MMP-1 gene expression in newborn foreskin dermal fibroblasts using conventional RT-PCR techniques (RT-PCR) [44] (and derived from this [47], [48], [49]).
wIRA Positive_regulation (induce) of Gene_expression (expression) of MMP-1 in fibroblasts
2) Confidence 0.02 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0.06 Pain Relevance 0
In contrast, wIRA(+RL) did not produce cell death and did not induce a systematic increase in MMP-1 mRNA expression (less than twofold expression, within the laboratory range of fluctuation) detectable with the sensitive methods applied.
wIRA Positive_regulation (increase) of Gene_expression (expression) of MMP-1 mRNA associated with death
3) Confidence 0.02 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.16 Pain Relevance 0

General Comments

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