INT274724

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.74
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TBL1XR1) small molecule metabolic process (TBL1XR1) histone binding (TBL1XR1)
nucleolus (TBL1XR1) nucleus (TBL1XR1) DNA binding (TBL1XR1)
Anatomy Link Frequency
skin 2
fibroblasts 1
TBL1XR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 20 96.72 Very High Very High Very High
metalloproteinase 6 93.88 High High
Pain 110 78.56 Quite High
Inflammation 18 74.56 Quite High
Analgesic 12 64.56 Quite High
imagery 10 33.16 Quite Low
visual analogue scale 14 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 216 99.86 Very High Very High Very High
Injury 120 98.22 Very High Very High Very High
Nicotine Addiction 8 97.08 Very High Very High Very High
Cv General 3 Under Development 20 96.72 Very High Very High Very High
Aging 6 95.60 Very High Very High Very High
Wound Healing 90 87.96 High High
Pain 110 78.56 Quite High
INFLAMMATION 18 74.56 Quite High
Wound Infection 6 64.68 Quite High
Diabetes Mellitus 8 64.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mode C, the two dyes were applied and immediately afterwards the skin was irradiated with wIRA over 30 min.
Positive_regulation (irradiated) of wIRA in skin
1) Confidence 0.12 Published 2008 Journal GMS German Medical Science Section Abstract Doc Link PMC2703260 Disease Relevance 0 Pain Relevance 0
Skin surface temperature increased from 32.8°C before wIRA to 36.4°C after wIRA irradiation.
Positive_regulation (increased) of wIRA in Skin
2) Confidence 0.12 Published 2008 Journal GMS German Medical Science Section Abstract Doc Link PMC2703260 Disease Relevance 0 Pain Relevance 0
Typically for wIRA irradiation the wound has to be uncovered, as most bandages or wound dressings (with the exception of e.g. some tested transparent foils) are not adequately permeable for wIRA [18], [19].
Neg (not) Positive_regulation (permeable) of wIRA associated with injury
3) Confidence 0.04 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 1.06 Pain Relevance 0.25
Especially the only ulcer which increased slightly in size during the treatment period with wIRA had the severe concomitant problem of lacking compression garment therapy (patient 5, more details are available in Attachment 5).
Positive_regulation (increased) of wIRA associated with ulcers
4) Confidence 0.04 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 1.44 Pain Relevance 0.15
As devices emitting longer wavelengths are widely used in therapeutic and cosmetic interventions and as the induction of MMP-1 by water-filtered infrared-A (wIRA) had been discussed, it was of interest to assess effects of wIRA on the cellular and molecular level known to be possibly involved in cutaneous degeneration.
Positive_regulation (induction) of wIRA
5) Confidence 0.02 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.18 Pain Relevance 0.05
Both conventional Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) and quantitative real-time RT-PCR techniques were used to determine the induction of MMP-1 mRNA at two physiologic temperatures for skin fibroblasts (30°C and 37°C) in single exposure regimens (15-60 minutes wIRA(+RL), 340-1360 J/cm² wIRA(+RL), 300-1200 J/cm² wIRA; 30 minutes UV-A(+BL), 50 J/cm² UV-A(+BL)) and in addition at 30°C in a repeated exposure protocol (up to 10 times 15 minutes wIRA(+RL) with 340 J/cm² wIRA(+RL), 300 J/cm² wIRA at each time).
Positive_regulation (induction) of wIRA in fibroblasts
6) Confidence 0.02 Published 2007 Journal GMS German Medical Science Section Abstract Doc Link PMC2703241 Disease Relevance 0.05 Pain Relevance 0

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