INT274725

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.08
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TBL1XR1) small molecule metabolic process (TBL1XR1) histone binding (TBL1XR1)
nucleolus (TBL1XR1) nucleus (TBL1XR1) DNA binding (TBL1XR1)
Anatomy Link Frequency
fibroblasts 3
leg 1
TBL1XR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 20 91.20 High High
Pain 109 88.12 High High
Inflammation 18 5.00 Very Low Very Low Very Low
visual analogue scale 14 5.00 Very Low Very Low Very Low
Analgesic 12 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ulcers 216 98.32 Very High Very High Very High
Increased Venous Pressure Under Development 19 97.80 Very High Very High Very High
Cv General 3 Under Development 20 91.20 High High
Diabetes Mellitus 8 89.04 High High
Pain 109 88.12 High High
Nicotine Addiction 8 70.32 Quite High
Leg Ulcer 19 70.00 Quite High
Wound Healing 92 50.00 Quite Low
Venous Stasis Ulcers 46 50.00 Quite Low
Injury 120 41.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aim of the study: Investigation of the influence of wIRA irradiation on the dermatopharmacokinetics of topically applied substances by use of optical methods, especially to localize penetrating substances, in a prospective randomised controlled study in humans.
Regulation (influence) of wIRA
1) Confidence 0.11 Published 2008 Journal GMS German Medical Science Section Abstract Doc Link PMC2703260 Disease Relevance 0.10 Pain Relevance 0
In one patient (patient 10) a comparison between a control group radiator and a fully active radiator was possible to perform since the patient had an ulcer on each leg: the ulcer treated with wIRA healed completely, the other ulcer primarily treated with the control group radiator without wIRA became larger during the initial period with the control group radiator without wIRA and afterwards during wIRA treatment with the fully active radiator decreased markedly by 92%.
Regulation (during) of wIRA in leg associated with ulcers
2) Confidence 0.04 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 1.25 Pain Relevance 0.11
Assessment of the effect of wIRA treatment (all patients)
Regulation (effect) of wIRA
3) Confidence 0.04 Published 2008 Journal GMS German Medical Science Section Body Doc Link PMC2703263 Disease Relevance 0.73 Pain Relevance 0.53
Microscopic photos of cultured fibroblasts, representing 6 investigated different conditions of single irradiation (PBS control at 30°C, 680 J/cm² wIRA(+RL) at 30°C, 1360 J/cm² wIRA(+RL) at 30°C; PBS control at 37°C, 680 J/cm² wIRA(+RL) at 37°C, 1360 J/cm² wIRA(+RL) at 37°C), are shown in Figure 6.


Regulation (control) of wIRA in fibroblasts
4) Confidence 0.01 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0
Microscopic photos of cultured fibroblasts, representing 6 investigated different conditions of single irradiation (PBS control at 30°C, 680 J/cm² wIRA(+RL) at 30°C, 1360 J/cm² wIRA(+RL) at 30°C; PBS control at 37°C, 680 J/cm² wIRA(+RL) at 37°C, 1360 J/cm² wIRA(+RL) at 37°C), are shown in Figure 6.


Regulation (control) of wIRA in fibroblasts
5) Confidence 0.01 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0
Microscopic photos of cultured fibroblasts, representing 6 investigated different conditions of single irradiation (PBS control at 30°C, 680 J/cm² wIRA(+RL) at 30°C, 1360 J/cm² wIRA(+RL) at 30°C; PBS control at 37°C, 680 J/cm² wIRA(+RL) at 37°C, 1360 J/cm² wIRA(+RL) at 37°C), are shown in Figure 6.


Regulation (control) of wIRA in fibroblasts
6) Confidence 0.01 Published 2007 Journal GMS German Medical Science Section Body Doc Link PMC2703241 Disease Relevance 0 Pain Relevance 0

General Comments

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