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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mapk1, TNF) nucleoplasm (Mapk1) mitochondrion (Mapk1)
intracellular (TNF) extracellular matrix organization (TNF) protein complex (Mapk1)
Mapk1 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
allodynia 2 94.28 High High
Peripheral nerve injury 6 93.56 High High
Inflammation 21 92.48 High High
Spinal cord 2 85.80 High High
Cannabinoid receptor 6 50.00 Quite Low
Cannabinoid 6 42.08 Quite Low
Pain 3 31.28 Quite Low
chemokine 1 25.72 Quite Low
cytokine 2 25.24 Quite Low
Central nervous system 4 20.56 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 7 94.28 High High
Nervous System Injury 9 93.56 High High
INFLAMMATION 23 92.48 High High
Hypersensitivity 5 88.24 High High
Diabetes Mellitus 1 87.24 High High
Frailty 2 86.08 High High
Drug Induced Neurotoxicity 1 75.60 Quite High
Necrosis 3 70.92 Quite High
Cancer 3 70.56 Quite High
Pain 5 31.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that CBR2 activation reduces microglial p-ERK, and subsequently TNF production and cell migration.
Positive_regulation (activation) of ERK Negative_regulation (reduces) of Gene_expression (production) of TNF
1) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 1.08 Pain Relevance 0.35

General Comments

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