INT274881

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Dusp6) cytosol (Dusp6) cytoplasm (Dusp6)
Dusp6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 4 83.20 Quite High
Lasting pain 8 82.28 Quite High
addiction 8 77.60 Quite High
Neuropathic pain 16 76.20 Quite High
allodynia 8 69.20 Quite High
Peripheral nerve injury 24 68.48 Quite High
Pain 12 65.88 Quite High
agonist 40 65.28 Quite High
Inflammation 84 64.72 Quite High
Antinociceptive 4 64.28 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 20 87.32 High High
Pain 20 82.28 Quite High
Nervous System Injury 36 78.40 Quite High
Neuropathic Pain 28 76.20 Quite High
INFLAMMATION 92 64.72 Quite High
Necrosis 12 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data strongly suggest that the modulation of the MKP-3/p-ERK pathway is the mechanism by which CBR2 activation reduces microglial migration towards ADP.
Regulation (modulation) of MKP-3
1) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.90 Pain Relevance 0.60
In these studies we challenged JWH015's effects on MKP-1 and MKP-3 using three different compounds claimed to be MKP-1 inhibitors.
Regulation (effects) of MKP-3
2) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.04
PSI2106 or Ro-31-8220 did not modify JWH015's effects on MKP-3 at 1 ?
Neg (not) Regulation (effects) of MKP-3
3) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0
We investigated the functional implications of MKP-1 and MKP-3 modulation by studying ERK1/2 phosphorylation.
Spec (investigated) Regulation (modulation) of MKP-3
4) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0

General Comments

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